RAP1A

RAP1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C1Y, 1GUA, 3KUC, 4KVG
Identifiers
Aliases	RAP1A, C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21, member of RAS oncogene family
External IDs	MGI: 97852 HomoloGene: 2162 GeneCards: RAP1A
Gene ontology Molecular function • nucleotide binding • protein complex binding • GTP binding • Ras GTPase binding • protein transporter activity • protein binding • Rap guanyl-nucleotide exchange factor activity • GTPase activity Cellular component • cytosol • endosome • membrane • myelin sheath • plasma membrane • guanyl-nucleotide exchange factor complex • neuron projection • extracellular exosome • early endosome • late endosome • cytoplasm • cell junction • perinuclear region of cytoplasm • specific granule membrane • phagocytic vesicle Biological process • establishment of endothelial barrier • positive regulation of glucose import • microvillus assembly • regulation of cell junction assembly • activation of MAPKK activity • regulation of insulin secretion • small GTPase mediated signal transduction • Rap protein signal transduction • cellular response to organic cyclic compound • nervous system development • negative regulation of synaptic vesicle exocytosis • cellular response to drug • liver regeneration • protein transport • response to antineoplastic agent • response to carbohydrate • negative regulation of collagen biosynthetic process • cellular response to glucose stimulus • signal transduction • cellular response to nerve growth factor stimulus • nerve growth factor signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein kinase activity • positive regulation of vasculogenesis • positive regulation of GTPase activity • cellular response to cAMP • positive regulation of neuron projection development • neutrophil degranulation • positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5906	109905
Ensembl	ENSG00000116473	ENSMUSG00000068798
UniProt	P62834	P62835
RefSeq (mRNA)	NM_001010935 NM_001291896 NM_002884	NM_145541
RefSeq (protein)	NP_001010935 NP_001278825 NP_002875	NP_663516
Location (UCSC)	Chr 1: 111.54 – 111.72 Mb	Chr 3: 105.73 – 105.8 Mb
PubMed search

1C1Y, 1GUA, 3KUC, 4KVG

5906

109905

ENSG00000116473

ENSMUSG00000068798

P62834

P62835

NM_001010935
NM_001291896
NM_002884

NM_145541

NP_001010935
NP_001278825
NP_002875

NP_663516

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene.

The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

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