RALA

RALA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UAD, 1ZC3, 1ZC4, 2A78, 2A9K, 2BOV
Identifiers
Aliases	RALA, RAL, RALA Ras like proto-oncogene A
External IDs	MGI: 1927243 HomoloGene: 3942 GeneCards: RALA
Gene ontology Molecular function • Edg-2 lysophosphatidic acid receptor binding • nucleotide binding • GDP binding • myosin binding • ATPase binding • GTP binding • protein binding • GTPase activity • ubiquitin protein ligase binding Cellular component • membrane • focal adhesion • myelin sheath • plasma membrane • endocytic vesicle • cell surface • midbody • cleavage furrow • extracellular exosome • cytoplasmic vesicle membrane • intracellular Biological process • actin cytoskeleton reorganization • cytokinesis • cell division • regulation of exocytosis • chemotaxis • neural tube closure • membrane raft localization • cell cycle • membrane organization • viral process • positive regulation of filopodium assembly • signal transduction • exocytosis • Ras protein signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5898	56044
Ensembl	ENSG00000006451	ENSMUSG00000008859
UniProt	P11233	P63321
RefSeq (mRNA)	NM_005402	NM_019491
RefSeq (protein)	NP_005393	NP_062364.3 NP_062364
Location (UCSC)	Chr 7: 39.62 – 39.71 Mb	Chr 13: 17.88 – 17.94 Mb
PubMed search

1UAD, 1ZC3, 1ZC4, 2A78, 2A9K, 2BOV

5898

56044

ENSG00000006451

ENSMUSG00000008859

P11233

P63321

NM_005402

NM_019491

NP_005393

NP_062364.3
NP_062364

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

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