RAD51

RAD51
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N0W, 1B22
Identifiers
Aliases	RAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
External IDs	OMIM: 179617 MGI: 97890 HomoloGene: 2155 GeneCards: RAD51
Gene ontology Molecular function • nucleotide binding • DNA binding • DNA-dependent ATPase activity • recombinase activity • chromatin binding • DNA polymerase binding • protein C-terminus binding • protein binding • four-way junction DNA binding • identical protein binding • endodeoxyribonuclease activity • ATP binding • single-stranded DNA binding • double-stranded DNA binding • single-stranded DNA-dependent ATPase activity Cellular component • cytoplasm • site of double-strand break • PML body • cytoskeleton • nucleoplasm • microtubule organizing center • nuclear chromosome • mitochondrial matrix • nucleolus • mitochondrion • perinuclear region of cytoplasm • chromatin • condensed chromosome • nuclear chromosome, telomeric region • nucleus • nuclear chromatin • lateral element • cytosol • condensed nuclear chromosome Biological process • regulation of protein phosphorylation • strand invasion • mitotic recombination-dependent replication fork processing • reciprocal meiotic recombination • DNA recombination • response to organic cyclic compound • regulation of double-strand break repair via homologous recombination • DNA metabolic process • telomere organization • positive regulation of DNA ligation • cellular response to alkaloid • telomere maintenance via recombination • telomere maintenance via telomere lengthening • cellular response to camptothecin • double-strand break repair via homologous recombination • cellular response to gamma radiation • meiosis I • replication fork processing • cellular response to ionizing radiation • cellular response to cisplatin • chromosome organization involved in meiotic cell cycle • mitotic recombination • protein homooligomerization • response to toxic substance • DNA repair • response to X-ray • response to drug • DNA unwinding involved in DNA replication • cellular response to hydroxyurea • replication-born double-strand break repair via sister chromatid exchange • cellular response to DNA damage stimulus • strand displacement • DNA synthesis involved in DNA repair • interstrand cross-link repair • response to glucoside • DNA recombinase assembly • meiotic cell cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5888	19361
Ensembl	ENSG00000051180	ENSMUSG00000027323
UniProt	Q06609	Q08297
RefSeq (mRNA)	NM_001164269 NM_001164270 NM_002875 NM_133487	NM_011234
RefSeq (protein)	NP_001157741 NP_001157742 NP_002866 NP_597994	NP_035364.1 NP_035364
Location (UCSC)	Chr 15: 40.69 – 40.73 Mb	Chr 2: 119.11 – 119.15 Mb
PubMed search

1N0W, 1B22

5888

19361

ENSG00000051180

ENSMUSG00000027323

Q06609

Q08297

NM_001164269
NM_001164270
NM_002875
NM_133487

NM_011234

NP_001157741
NP_001157742
NP_002866
NP_597994

NP_035364.1
NP_035364

RAD51 is a eukaryote gene. The protein encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to humans.

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Wikipedia