| Route 281 | ||||
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| Route information | ||||
| Length: | 75.0 km (46.6 mi) | |||
| Major junctions | ||||
| North end: |
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| South end: |
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| Location | ||||
| Major cities: | Saint-Michel-de-Bellechasse | |||
| Highway system | ||||
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Route 281 is a 75 km two-lane north/south highway in the Chaudière-Appalaches region in the province of Quebec, Canada. Its northern terminus is in St-Michel at the junction of Route 132 and its southern terminus is close to Saint-Camille-de-Lellis at the junction of Route 204.