Pyruvate dehydrogenase (lipoamide) beta

PDHB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NI4, 2OZL, 3EXE, 3EXF, 3EXG, 3EXH, 3EXI
Identifiers
Aliases	PDHB, PDHBD, PDHE1-B, PHE1B, Pyruvate dehydrogenase (lipoamide) beta, PDHE1B, pyruvate dehydrogenase E1 beta subunit
External IDs	MGI: 1915513 HomoloGene: 712 GeneCards: PDHB
Gene location (Human) Chr. Chromosome 3 (human) Band 3p14.3 Start 58,427,630 bp End 58,433,857 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A1 Start 8,165,996 bp End 8,173,025 bp
Gene ontology Molecular function • pyruvate dehydrogenase activity • protein binding • catalytic activity • oxidoreductase activity • pyruvate dehydrogenase (acetyl-transferring) activity • pyruvate dehydrogenase (NAD+) activity Cellular component • pyruvate dehydrogenase complex • nucleoplasm • mitochondrial matrix • mitochondrion • extracellular exosome • nucleus Biological process • mitochondrial acetyl-CoA biosynthetic process from pyruvate • tricarboxylic acid cycle • regulation of acetyl-CoA biosynthetic process from pyruvate • pyruvate metabolic process • glucose metabolic process • metabolism • oxidation-reduction process • cellular nitrogen compound metabolic process • carbohydrate metabolic process • acetyl-CoA biosynthetic process from pyruvate Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5162	68263
Ensembl	ENSG00000168291	ENSMUSG00000021748
UniProt	P11177	Q9D051
RefSeq (mRNA)	NM_000925 NM_001173468 NM_001315536	NM_024221
RefSeq (protein)	NP_000916 NP_001166939 NP_001302465	NP_077183
Location (UCSC)	Chr 3: 58.43 – 58.43 Mb	Chr 3: 8.17 – 8.17 Mb
PubMed search

1NI4, 2OZL, 3EXE, 3EXF, 3EXG, 3EXH, 3EXI

5162

68263

ENSG00000168291

ENSMUSG00000021748

P11177

Q9D051

NM_000925
NM_001173468
NM_001315536

NM_024221

NP_000916
NP_001166939
NP_001302465

NP_077183

Pyruvate dehydrogenase (lipoamide) beta, also known as pyruvate dehydrogenase E1 component subunit beta, mitochondrial or PDHE1-B is an enzyme that in humans is encoded by the PDHB gene. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO₂, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency.

...
Wikipedia