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Pyruvate carboxylase

Pyruvate carboxylase
Pyruvate Carboxylase fromPDB 2QF7.png
Crystallographic structure of pyruvate carboxylase from Rhizobium etli: biotin carboxylase domain (blue); allosteric linking domain (green); biotin binding domain (red); and carboxyl transferase domain (orange)
Identifiers
EC number 6.4.1.1
CAS number 9014-19-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Pyruvate carboxyltransferase
Identifiers
Symbol PYR_CT
Pfam PF00682
InterPro IPR000891
PROSITE PDOC50991
Pyruvate carboxylase
Identifiers
Symbol PC
Entrez 5091
HUGO 8636
OMIM 608786
RefSeq NM_000920
UniProt P11498
Other data
EC number 6.4.1.1
Locus Chr. 11 q11-q13.1
PC
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PC, pyruvate carboxylase, PCB
External IDs MGI: 97520 HomoloGene: 5422 GeneCards: PC
Genetically Related Diseases
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000920
NM_001040716
NM_022172

NM_001162946
NM_008797

RefSeq (protein)

NP_000911
NP_001035806
NP_071504

n/a

Location (UCSC) Chr 11: 66.85 – 66.96 Mb Chr 19: 4.51 – 4.62 Mb
PubMed search

3BG3, 3BG9

NM_000920
NM_001040716
NM_022172

NM_001162946
NM_008797

NP_000911
NP_001035806
NP_071504

n/a

Pyruvate carboxylase (PC) is an enzyme of the ligase class that catalyzes (depending on the species) the physiologically irreversible carboxylation of pyruvate to form oxaloacetate (OAA).


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Wikipedia

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