Pyridoxine deficiency

Vitamin B6
Drug class
Pyridoxal phosphate
Class identifiers
Use	Vitamin B6 deficiency
ATC code	A11HA02
Biological target	enzyme cofactor
Clinical data
Drugs.com	International Drug Names
External links
MeSH	D025101

Vitamin B₆ refers to a group of chemically very similar compounds which can be interconverted in biological systems. Vitamin B₆ is part of the vitamin B group, and its active form, pyridoxal 5′-phosphate (PLP) serves as a coenzyme in many enzyme reactions in amino acid, glucose, and lipid metabolism.

Several forms (vitamers) of vitamin B₆ are known:

All forms except pyridoxic acid and pyritinol can be interconverted. Absorbed pyridoxamine is converted to PMP by pyridoxal kinase, which is further converted to PLP by pyridoxamine-phosphate transaminase or pyridoxine 5′-phosphate oxidase which also catalyzes the conversion of PNP to PLP. Pyridoxine 5′-phosphate oxidase is dependent on flavin mononucleotide (FMN) as a cofactor which is produced from riboflavin (vitamin B₂) i.e. in this biochemical pathway, dietary vitamin B₆ cannot be used without vitamin B₂.

PLP, the metabolically active form of vitamin B₆, is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gene expression. PLP generally serves as a coenzyme (cofactor) for many reactions including decarboxylation, transamination, racemization, elimination, replacement, and beta-group interconversion. The liver is the site for vitamin B₆ metabolism.

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