Pseudomonas exotoxin

The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.

It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2. This then causes the elongation of polypeptides to cease.(The mechanism of the toxin is similar to that of Diphtheria toxin.)

It has been investigated as a treatment for hepatitis B and cancer.

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