Proteolipid protein

PLP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XPG
Identifiers
Aliases	PLP1, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2, proteolipid protein 1
External IDs	OMIM: 300401 MGI: 97623 HomoloGene: 448 GeneCards: PLP1
Gene ontology Molecular function • protein binding • structural constituent of myelin sheath • structural molecule activity Cellular component • integral component of membrane • myelin sheath • plasma membrane • membrane Biological process • axon ensheathment • integrin-mediated signaling pathway • astrocyte development • myelination • axon development • positive regulation of gene expression • inflammatory response • glial cell differentiation • cell maturation • long-chain fatty acid biosynthetic process • substantia nigra development • central nervous system myelination • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5354	18823
Ensembl	ENSG00000123560	ENSMUSG00000031425
UniProt	P60201	P60202
RefSeq (mRNA)	NM_199478 NM_000533 NM_001128834 NM_001305004	NM_011123 NM_001290561 NM_001290562
RefSeq (protein)	NP_000524 NP_001122306 NP_001291933 NP_955772	NP_001277490.1 NP_001277491.1 NP_035253.1 NP_001277490 NP_001277491 NP_035253
Location (UCSC)	Chr X: 103.77 – 103.79 Mb	Chr X: 136.82 – 136.84 Mb
PubMed search

2XPG

5354

18823

ENSG00000123560

ENSMUSG00000031425

P60201

P60202

NM_199478
NM_000533
NM_001128834
NM_001305004

NM_011123
NM_001290561
NM_001290562

NP_000524
NP_001122306
NP_001291933
NP_955772

NP_035253

Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane. In a myelin sheath, as the layers of myelin wraps come together, PLP will bind itself and tightly hold the cellular membranes together.

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Wikipedia