Proteinase 3

PRTN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FUJ
Identifiers
Aliases	PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDs	OMIM: 177020 MGI: 893580 HomoloGene: 120934 GeneCards: PRTN3
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 840,960 bp End 848,175 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 39.72 cM Start 79,874,476 bp End 79,883,174 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • enzyme binding • peptidase activity • serine-type peptidase activity • hydrolase activity • protein binding • serine-type endopeptidase activity • receptor binding Cellular component • extracellular matrix • plasma membrane • extracellular exosome • cytosol • extracellular region • extracellular space • azurophil granule lumen • plasma membrane raft Biological process • collagen catabolic process • blood coagulation • negative regulation of phagocytosis • mature conventional dendritic cell differentiation • positive regulation of cell proliferation • antimicrobial humoral response • neutrophil degranulation • proteolysis • membrane protein ectodomain proteolysis • positive regulation of GTPase activity • cell-cell junction maintenance • neutrophil extravasation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5657	19152
Ensembl	ENSG00000277804 ENSG00000196415	ENSMUSG00000057729
UniProt	P24158	Q61096
RefSeq (mRNA)	NM_002777	NM_011178
RefSeq (protein)	NP_002768	NP_035308
Location (UCSC)	Chr 19: 0.84 – 0.85 Mb	Chr 19: 79.87 – 79.88 Mb
PubMed search

1FUJ

5657

19152

ENSG00000277804
ENSG00000196415

ENSMUSG00000057729

P24158

Q61096

NM_002777

NM_011178

NP_002768

NP_035308

Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene.

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").

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