Protein tyrosine phosphatase 1B

PTPN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F, 1G7G, 1GFY, 1I57, 1JF7, 1KAK, 1KAV, 1L8G, 1LQF, 1NL9, 1NNY, 1NO6, 1NWE, 1NWL, 1NZ7, 1OEM, 1OEO, 1OES, 1OET, 1OEV, 1ONY, 1ONZ, 1PA1, 1PH0, 1PTT, 1PTU, 1PTV, 1PTY, 1PXH, 1PYN, 1Q1M, 1Q6J, 1Q6M, 1Q6N, 1Q6P, 1Q6S, 1Q6T, 1QXK, 1SUG, 1T48, 1T49, 1T4J, 1WAX, 1XBO, 2AZR, 2B07, 2B4S, 2BGD, 2BGE, 2CM2, 2CM3, 2CM7, 2CM8, 2CMA, 2CMB, 2CMC, 2CNE, 2CNF, 2CNG, 2CNH, 2CNI, 2F6F, 2F6T, 2F6V, 2F6W, 2F6Y, 2F6Z, 2F70, 2F71, 2FJM, 2FJN, 2H4G, 2H4K, 2HB1, 2HNP, 2HNQ, 2NT7, 2NTA, 2QBP, 2QBQ, 2QBR, 2QBS, 2VEU, 2VEV, 2VEW, 2VEX, 2VEY, 2ZMM, 2ZN7, 3A5J, 3A5K, 3CWE, 3D9C, 3EAX, 3EB1, 3EU0, 3I7Z, 3I80, 3QKP, 3QKQ, 3SME, 3ZMP, 3ZMQ, 3ZV2, 4BJO, 4I8N, 4QAH, 4QAP, 4QBE, 4QBW, 4Y14, 4ZRT
Identifiers
Aliases	PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1
External IDs	MGI: 97805 HomoloGene: 2119 GeneCards: PTPN1
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.13 Start 50,510,321 bp End 50,585,241 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 167,932,057 bp End 167,979,385 bp
Gene ontology Molecular function • phosphoprotein phosphatase activity • insulin receptor binding • phosphatase activity • ephrin receptor binding • receptor tyrosine kinase binding • zinc ion binding • protein binding • protein tyrosine phosphatase activity • protein phosphatase 2A binding • enzyme binding • hydrolase activity • protein kinase binding • RNA binding • cadherin binding Cellular component • cytoplasm • cytosol • endoplasmic reticulum membrane • membrane • plasma membrane • early endosome • endoplasmic reticulum • cytoplasmic side of endoplasmic reticulum membrane • sorting endosome • cytoplasmic vesicle Biological process • activation of signaling protein activity involved in unfolded protein response • regulation of endocytosis • actin cytoskeleton reorganization • insulin receptor signaling pathway • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity • activation of JUN kinase activity • negative regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein tyrosine kinase activity • protein dephosphorylation • regulation of hepatocyte growth factor receptor signaling pathway • response to endoplasmic reticulum stress • endoplasmic reticulum unfolded protein response • regulation of intracellular protein transport • positive regulation of IRE1-mediated unfolded protein response • negative regulation of insulin receptor signaling pathway • IRE1-mediated unfolded protein response • regulation of type I interferon-mediated signaling pathway • regulation of signal transduction • negative regulation of MAP kinase activity • positive regulation of receptor catabolic process • negative regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine dephosphorylation • negative regulation of PERK-mediated unfolded protein response • regulation of insulin receptor signaling pathway • platelet-derived growth factor receptor-beta signaling pathway • dephosphorylation • negative regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5770	19246
Ensembl	ENSG00000196396	ENSMUSG00000027540
UniProt	P18031	P35821
RefSeq (mRNA)	NM_002827 NM_001278618	NM_011201
RefSeq (protein)	NP_001265547 NP_002818	NP_035331
Location (UCSC)	Chr 20: 50.51 – 50.59 Mb	Chr 20: 167.93 – 167.98 Mb
PubMed search

1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F, 1G7G, 1GFY, 1I57, 1JF7, 1KAK, 1KAV, 1L8G, 1LQF, 1NL9, 1NNY, 1NO6, 1NWE, 1NWL, 1NZ7, 1OEM, 1OEO, 1OES, 1OET, 1OEV, 1ONY, 1ONZ, 1PA1, 1PH0, 1PTT, 1PTU, 1PTV, 1PTY, 1PXH, 1PYN, 1Q1M, 1Q6J, 1Q6M, 1Q6N, 1Q6P, 1Q6S, 1Q6T, 1QXK, 1SUG, 1T48, 1T49, 1T4J, 1WAX, 1XBO, 2AZR, 2B07, 2B4S, 2BGD, 2BGE, 2CM2, 2CM3, 2CM7, 2CM8, 2CMA, 2CMB, 2CMC, 2CNE, 2CNF, 2CNG, 2CNH, 2CNI, 2F6F, 2F6T, 2F6V, 2F6W, 2F6Y, 2F6Z, 2F70, 2F71, 2FJM, 2FJN, 2H4G, 2H4K, 2HB1, 2HNP, 2HNQ, 2NT7, 2NTA, 2QBP, 2QBQ, 2QBR, 2QBS, 2VEU, 2VEV, 2VEW, 2VEX, 2VEY, 2ZMM, 2ZN7, 3A5J, 3A5K, 3CWE, 3D9C, 3EAX, 3EB1, 3EU0, 3I7Z, 3I80, 3QKP, 3QKQ, 3SME, 3ZMP, 3ZMQ, 3ZV2, 4BJO, 4I8N, 4QAH, 4QAP, 4QBE, 4QBW, 4Y14, 4ZRT

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