Protein kinase R

EIF2AK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UIU, 1QU6, 2A19, 2A1A
Identifiers
Aliases	EIF2AK2, EIF2AK1, PKR, PPP1R83, PRKR, eukaryotic translation initiation factor 2 alpha kinase 2
External IDs	OMIM: 176871 MGI: 1353449 HomoloGene: 48134 GeneCards: EIF2AK2
EC number	2.7.10.2
Targeted by Drug
PKR inhibitor
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • double-stranded RNA binding • protein tyrosine kinase activity • ATP binding • eukaryotic translation initiation factor 2alpha kinase activity • protein phosphatase regulator activity • RNA binding Cellular component • cytoplasm • ribosome • membrane • perinuclear region of cytoplasm • nucleus • cytosol Biological process • negative regulation of translation • regulation of hematopoietic stem cell proliferation • regulation of transcription, DNA-templated • translation • positive regulation of cytokine production • activation of MAPKK activity • immune system process • phosphorylation • cellular response to amino acid starvation • negative regulation of apoptotic process • evasion or tolerance by virus of host immune response • positive regulation of NIK/NF-kappaB signaling • transcription, DNA-templated • endoplasmic reticulum unfolded protein response • protein phosphorylation • negative regulation of viral genome replication • regulation of hematopoietic stem cell differentiation • regulation of hematopoietic progenitor cell differentiation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • response to interferon-alpha • positive regulation of chemokine production • negative regulation of osteoblast proliferation • protein autophosphorylation • regulation of NLRP3 inflammasome complex assembly • peptidyl-tyrosine phosphorylation • innate immune response • viral process • response to toxic substance • positive regulation of stress-activated MAPK cascade • response to virus • regulation of translational initiation by eIF2 alpha phosphorylation • regulation of apoptotic process • negative regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5610	19106
Ensembl	ENSG00000055332	ENSMUSG00000024079
UniProt	P19525	Q03963
RefSeq (mRNA)	NM_001135651 NM_001135652 NM_002759	NM_011163
RefSeq (protein)	NP_001129123 NP_001129124 NP_002750	NP_035293.1 NP_035293
Location (UCSC)	Chr 2: 37.1 – 37.16 Mb	Chr 17: 78.85 – 78.88 Mb
PubMed search

3UIU, 1QU6, 2A19, 2A1A

5610

19106

ENSG00000055332

ENSMUSG00000024079

P19525

Q03963

NM_001135651
NM_001135652
NM_002759

NM_011163

NP_001129123
NP_001129124
NP_002750

NP_035293.1
NP_035293

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene.

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