Protein kinase Mζ

PRKCZ
Identifiers
Aliases	PRKCZ, PKC-ZETA, PKC2, protein kinase C zeta
External IDs	MGI: 97602 HomoloGene: 55681 GeneCards: PRKCZ
Gene ontology Molecular function • phospholipase binding • protein domain specific binding • kinase activity • ATP binding • protein kinase activity • metal ion binding • protein serine/threonine kinase activity • insulin receptor substrate binding • transferase activity • 14-3-3 protein binding • potassium channel regulator activity • protein binding • protein kinase binding • nucleotide binding • protein kinase C activity Cellular component • cytoplasm • filamentous actin • endosome • nuclear envelope • membrane • cell-cell junction • bicellular tight junction • microtubule organizing center • apical cortex • perinuclear region of cytoplasm • nucleus • nuclear matrix • apical plasma membrane • membrane raft • extracellular exosome • intracellular membrane-bounded organelle • protein complex • myelin sheath abaxonal region • cell cortex • vesicle • cell junction • cell leading edge • axon hillock • cytosol • plasma membrane Biological process • positive regulation of glucose import • insulin receptor signaling pathway • protein heterooligomerization • negative regulation of hydrolase activity • protein kinase C signaling • protein phosphorylation • negative regulation of insulin receptor signaling pathway • cell surface receptor signaling pathway • activation of phospholipase D activity • positive regulation of synaptic transmission • positive regulation of ERK1 and ERK2 cascade • positive regulation of excitatory postsynaptic potential • transforming growth factor beta receptor signaling pathway • negative regulation of protein complex assembly • negative regulation of peptidyl-tyrosine phosphorylation • positive regulation of interleukin-13 secretion • establishment of cell polarity • cellular response to insulin stimulus • protein localization to plasma membrane • inflammatory response • phosphorylation • positive regulation of cell-matrix adhesion • membrane depolarization • negative regulation of apoptotic process • positive regulation of interleukin-4 production • positive regulation of protein transport • positive regulation of NF-kappaB transcription factor activity • positive regulation of insulin receptor signaling pathway • positive regulation of T-helper 2 cell cytokine production • microtubule cytoskeleton organization • actin cytoskeleton reorganization • positive regulation of interleukin-5 secretion • activation of protein kinase B activity • membrane hyperpolarization • vesicle transport along microtubule • neuron projection extension • cellular protein localization • long-term memory • peptidyl-serine phosphorylation • positive regulation of cell proliferation • positive regulation of T-helper 2 cell differentiation • cell migration • signal transduction • long-term synaptic potentiation • positive regulation of interleukin-10 secretion • intracellular signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5590	18762
Ensembl	ENSG00000067606	ENSMUSG00000029053
UniProt	Q05513	Q02956
RefSeq (mRNA)	NM_001033581 NM_001033582 NM_001242874 NM_002744 NM_001350803 NM_001350804 NM_001350805 NM_001350806	NM_001039079 NM_008860
RefSeq (protein)	NP_001028753 NP_001028754 NP_001229803 NP_002735 NP_001337732 NP_001337733 NP_001337734 NP_001337735	NP_032886.2 NP_001034168 NP_032886
Location (UCSC)	Chr 1: 2.05 – 2.19 Mb	Chr 4: 155.26 – 155.36 Mb
PubMed search

5590

18762

ENSG00000067606

ENSMUSG00000029053

Q05513

Q02956

NM_001350804
NM_001350805
NM_001350806

NM_001039079
NM_008860

NP_001337733
NP_001337734
NP_001337735

NP_032886.2
NP_001034168
NP_032886

Protein kinase C, zeta (PKCζ), also known as PRKCZ, is an protein that in humans is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. The importance of PKCζ in the creation and maintenance of long-term potentiation was first described by Todd Sacktor and his colleagues at the State University of New York at Brooklyn in 1993.

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