Protein kinase D1

PRKD1
Identifiers
Aliases	PRKD1, PKC-MU, PKCM, PKD, PRKCM, Protein kinase D1, CHDED
External IDs	MGI: 99879 HomoloGene: 55680 GeneCards: PRKD1
Gene location (Human) Chr. Chromosome 14 (human) Band No data available Start 29,576,479 bp End 30,191,898 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band No data available Start 50,341,231 bp End 50,649,098 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase C activity • metal ion binding • kinase activity • protein binding • identical protein binding • ATP binding • protein serine/threonine kinase activity Cellular component • Golgi apparatus • membrane • plasma membrane • integral component of plasma membrane • autophagosome membrane • cytoplasm • trans-Golgi network • cytosol Biological process • negative regulation of endocytosis • cell differentiation • intracellular signal transduction • positive regulation of endothelial cell proliferation • regulation of protein stability • Golgi organization • phosphorylation • immune system process • positive regulation of endothelial cell chemotaxis • protein kinase D signaling • sphingolipid biosynthetic process • negative regulation of cell death • nervous system development • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • positive regulation of endothelial cell migration • protein phosphorylation • positive regulation of histone deacetylase activity • positive regulation of CREB transcription factor activity • vascular endothelial growth factor receptor signaling pathway • regulation of integrin-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of neuron projection development • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • integrin-mediated signaling pathway • protein autophosphorylation • cellular response to oxidative stress • cellular response to vascular endothelial growth factor stimulus • Ras protein signal transduction • cell proliferation • inflammatory response • innate immune response • signal transduction • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • positive regulation of autophagy • cellular response to amino acid starvation • positive regulation of phosphatidylinositol 3-kinase activity • cellular response to hydroperoxide • regulation of keratinocyte proliferation • positive regulation of osteoblast differentiation • Golgi vesicle transport • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5587	18760
Ensembl	ENSG00000184304	ENSMUSG00000002688
UniProt	Q15139	Q62101
RefSeq (mRNA)	NM_002742 NM_001330069 NM_001348390	NM_008858
RefSeq (protein)	NP_001316998 NP_002733 NP_001335319	NP_032884
Location (UCSC)	Chr 14: 29.58 – 30.19 Mb	Chr 14: 50.34 – 50.65 Mb
PubMed search

5587

18760

ENSG00000184304

ENSMUSG00000002688

Q15139

Q62101

NM_002742
NM_001330069
NM_001348390

NM_008858

NP_001316998
NP_002733
NP_001335319

NP_032884

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM]

Protein kinase D1 has been shown to interact with:

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Wikipedia