Protein Z-related protease inhibitor

Crystal structure of protein Z-dependent peptidase inhibitor (red) in complex with protein Z (blue). Rendered from PDB 3F1S
Identifiers
Symbol	SERPINA10
Entrez	51156
HUGO	15996
OMIM	605271
RefSeq	NM_016186
UniProt	Q9UK55
Other data
Locus	Chr. 14 q32.1

Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.

It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.

Water et al. found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).

Han et al. first described ZPI in 1998. The same group further characterised it in 2000.