Prostaglandin EP4 receptor

PTGER4
Identifiers
Aliases	PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
External IDs	MGI: 104311 HomoloGene: 20261 GeneCards: PTGER4
Gene ontology Molecular function • G-protein coupled receptor activity • prostaglandin receptor activity • signal transducer activity • protein binding • prostaglandin E receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • intracellular Biological process • G-protein coupled receptor signaling pathway • negative regulation of integrin activation • positive regulation of inflammatory response • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • positive regulation of cytokine secretion • ERK1 and ERK2 cascade • response to mechanical stimulus • negative regulation of eosinophil extravasation • regulation of stress fiber assembly • JNK cascade • cellular response to mechanical stimulus • response to lipopolysaccharide • negative regulation of cytokine secretion • immune response • regulation of ossification • T-helper cell differentiation • bone development • negative regulation of inflammatory response • signal transduction • cellular response to prostaglandin E stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5734	19219
Ensembl	ENSG00000171522	ENSMUSG00000039942
UniProt	P35408	P32240
RefSeq (mRNA)	NM_000958	NM_001136079 NM_008965
RefSeq (protein)	NP_000949	NP_001129551 NP_032991
Location (UCSC)	Chr 5: 40.68 – 40.69 Mb	Chr 15: 5.21 – 5.24 Mb
PubMed search

5734

19219

ENSG00000171522

ENSMUSG00000039942

P35408

P32240

NM_000958

NM_001136079
NM_008965

NP_000949

NP_001129551
NP_032991

Prostaglandin E₂ receptor 4 (EP₄) is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the PTGER4 gene in humans; it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₃, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP₄ has been implicated in various physiological and pathological responses in animal models and humans.

The PTGER4 gene is located on human chromosome 5p13.1 at position p13.1 (i.e. 5p13.1), contains 7 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14).

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Wikipedia