Prostaglandin EP3 receptor

PTGER3
Identifiers
Aliases	PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3
External IDs	MGI: 97795 HomoloGene: 105703 GeneCards: PTGER3
Gene ontology Molecular function • G-protein coupled receptor activity • prostaglandin receptor activity • signal transducer activity • prostaglandin E receptor activity • protein binding Cellular component • nuclear envelope • membrane • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • G-protein coupled receptor signaling pathway • positive regulation of fever generation • cell death • signal transduction • negative regulation of gastric acid secretion • phospholipase C-activating G-protein coupled receptor signaling pathway • intestine smooth muscle contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5733	19218
Ensembl	ENSG00000050628	ENSMUSG00000040016
UniProt	P43115	P30557
RefSeq (mRNA)	NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720	NM_011196
RefSeq (protein)	NP_001119516 NP_942007 NP_942008 NP_942009 NP_942010 NP_942011 NP_942012	n/a
Location (UCSC)	Chr 1: 70.85 – 71.05 Mb	Chr 3: 157.57 – 157.65 Mb
PubMed search

5733

19218

ENSG00000050628

ENSMUSG00000040016

P43115

P30557

NM_198715
NM_198716
NM_198717
NM_198718
NM_198719
NM_198720

NM_011196

NP_942011
NP_942012

n/a

Prostaglandin EP₃ receptor (53kDa), also known as EP₃, is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the human gene PTGER3; it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₄, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological and pathological responses.

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