Prostaglandin EP1 receptor

PTGER1
Identifiers
Aliases	PTGER1, EP1, EP1 receptor, prostaglandin E receptor 1
External IDs	MGI: 97793 HomoloGene: 738 GeneCards: PTGER1
Gene ontology Molecular function • prostaglandin receptor activity • G-protein coupled receptor activity • signal transducer activity • prostaglandin E receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5731	19216
Ensembl	ENSG00000160951	ENSMUSG00000019464
UniProt	P34995	P35375
RefSeq (mRNA)	NM_000955	NM_013641
RefSeq (protein)	NP_000946	NP_038669
Location (UCSC)	Chr 19: 14.47 – 14.48 Mb	Chr 8: 83.67 – 83.67 Mb
PubMed search

5731

19216

ENSG00000160951

ENSMUSG00000019464

P34995

P35375

NM_000955

NM_013641

NP_000946

NP_038669

Prostaglandin E₂ receptor 1 (EP₁) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. EP₁ is one of four identified EP receptors, EP₁, EP₂, EP₃, and EP₄ which bind with and mediate cellular responses principally to prostaglandin E₂) (PGE₂) and also but generally with lesser affinity and responsiveness to certain other prostanoids (see Prostaglandin receptors). Animal model studies have implicated EP₁ in various physiological and pathological responses. However, key differences in the distribution of EP₁ between these test animals and humans as well as other complicating issues make it difficult to establish the function(s) of this receptor in human health and disease.

The PTGER₁ gene is located on human chromosome 19 at position p13.12 (i.e. 19p13.12), contains 2 introns and 3 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14).

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Wikipedia