Prosaposin

PSAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M12, 1N69, 1SN6, 2DOB, 2GTG, 2QYP, 2R0R, 2R1Q, 2RB3, 2Z9A, 3BQP, 3BQQ, 4DDJ, 4UEX, 4V2O
Identifiers
Aliases	PSAP, GLBA, SAP1, prosaposin
External IDs	OMIM: 176801 MGI: 97783 HomoloGene: 37680 GeneCards: PSAP
Gene ontology Molecular function • G-protein coupled receptor binding • protein binding • lipid binding • enzyme activator activity • beta-galactosidase activity • phospholipid binding • protein homodimerization activity • ganglioside GM1 binding • ganglioside GM2 binding • ganglioside GM3 binding • ganglioside GT1b binding • ganglioside GP1c binding Cellular component • extracellular region • lysosomal membrane • integral component of membrane • mitochondrion • lysosomal lumen • extracellular exosome • extracellular space • lysosome • plasma membrane • azurophil granule membrane • intracellular membrane-bounded organelle Biological process • lipid metabolic process • lipid transport • epithelial cell differentiation involved in prostate gland development • regulation of MAPK cascade • glycosphingolipid metabolic process • developmental growth • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • regulation of autophagy • positive regulation of MAPK cascade • cellular response to organic substance • negative regulation of hydrogen peroxide-induced cell death • regulation of lipid metabolic process • prostate gland growth • platelet degranulation • sphingolipid metabolic process • positive regulation of catalytic activity • neutrophil degranulation • ganglioside GM1 transport to membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5660	19156
Ensembl	ENSG00000197746	ENSMUSG00000004207
UniProt	P07602 Q5BJH1	Q61207
RefSeq (mRNA)	NM_002778 NM_001042465 NM_001042466	NM_001146120 NM_001146121 NM_001146122 NM_001146123 NM_001146124 NM_011179
RefSeq (protein)	NP_001035930 NP_001035931 NP_002769 NP_002769.1	NP_001139592 NP_001139593 NP_001139594 NP_001139595 NP_001139596 NP_035309
Location (UCSC)	Chr 10: 71.82 – 71.85 Mb	Chr 10: 60.28 – 60.3 Mb
PubMed search

1M12, 1N69, 1SN6, 2DOB, 2GTG, 2QYP, 2R0R, 2R1Q, 2RB3, 2Z9A, 3BQP, 3BQQ, 4DDJ, 4UEX, 4V2O

5660

19156

ENSG00000197746

ENSMUSG00000004207

P07602
Q5BJH1

Q61207

NM_002778
NM_001042465
NM_001042466

...
Wikipedia