Promyelocytic leukemia zinc finger

ZBTB16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BUO, 1CS3
Identifiers
Aliases	ZBTB16, PLZF, ZNF145, zinc finger and BTB domain containing 16
External IDs	MGI: 103222 HomoloGene: 21214 GeneCards: ZBTB16
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • protein homodimerization activity • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • metal ion binding • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding • protein C-terminus binding • protein binding • identical protein binding • nucleic acid binding • double-stranded DNA binding Cellular component • PML body • nuclear speck • nuclear body • plasma membrane • transcriptional repressor complex • nucleus • cytosol • protein complex Biological process • embryonic hindlimb morphogenesis • forelimb morphogenesis • skeletal system development • myeloid cell differentiation • hemopoiesis • regulation of transcription, DNA-templated • embryonic pattern specification • embryonic digit morphogenesis • positive regulation of ossification • negative regulation of transcription from RNA polymerase II promoter • hindlimb morphogenesis • transcription, DNA-templated • mesonephros development • positive regulation of transcription, DNA-templated • central nervous system development • cartilage development • male germ-line stem cell asymmetric division • positive regulation of cartilage development • protein ubiquitination • positive regulation of chondrocyte differentiation • positive regulation of apoptotic process • protein localization to nucleus • positive regulation of NK T cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of fat cell differentiation • negative regulation of myeloid cell differentiation • anterior/posterior pattern specification • negative regulation of cell proliferation • apoptotic process • post-translational protein modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7704	235320
Ensembl	ENSG00000109906	ENSMUSG00000066687
UniProt	Q05516	Q3UQ17
RefSeq (mRNA)	NM_001018011 NM_006006	NM_001033324
RefSeq (protein)	NP_001018011 NP_005997	NP_001028496
Location (UCSC)	Chr 11: 114.06 – 114.25 Mb	Chr 9: 48.65 – 48.84 Mb
PubMed search

1BUO, 1CS3

7704

235320

ENSG00000109906

ENSMUSG00000066687

Q05516

Q3UQ17

NM_001018011
NM_006006

NM_001033324

NP_001018011
NP_005997

NP_001028496

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.

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