Promyelocytic leukemia protein

PML

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BOR, 2MVW, 2MWX, 4WJN, 4WJO

Identifiers

Aliases

PML, MYL, PP8675, RNF71, TRIM19, Promyelocytic leukemia protein, promyelocytic leukemia, Probable transcription factor PML

External IDs

MGI: 104662 HomoloGene: 13245 GeneCards: PML

Genetically Related Diseases

myopia, mammary Paget's disease

Gene ontology
Molecular function	• SUMO binding • cobalt ion binding • metal ion binding • protein homodimerization activity • zinc ion binding • protein binding • SMAD binding • DNA binding • transcription coactivator activity • protein heterodimerization activity • ubiquitin protein ligase binding
Cellular component	• cytoplasm • cytosol • endosome • nuclear membrane • membrane • nuclear chromosome, telomeric region • nucleus • nuclear matrix • nucleolus • endoplasmic reticulum • early endosome membrane • intracellular • nucleoplasm • PML body • endoplasmic reticulum membrane • extrinsic component of endoplasmic reticulum membrane
Biological process	• regulation of protein phosphorylation • positive regulation of histone deacetylation • intrinsic apoptotic signaling pathway in response to oxidative stress • myeloid cell differentiation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of telomere maintenance via telomerase • rhythmic process • interferon-gamma-mediated signaling pathway • negative regulation of telomerase activity • cell aging • positive regulation of telomere maintenance • cellular senescence • regulation of cell adhesion • defense response to virus • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • transforming growth factor beta receptor signaling pathway • negative regulation of interleukin-1 beta secretion • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of cell proliferation • positive regulation of defense response to virus by host • apoptotic process • response to cytokine • cell fate commitment • negative regulation of translation in response to oxidative stress • regulation of transcription, DNA-templated • common-partner SMAD protein phosphorylation • branching involved in mammary gland duct morphogenesis • extrinsic apoptotic signaling pathway • SMAD protein import into nucleus • positive regulation of fibroblast proliferation • positive regulation of apoptotic signaling pathway • endoplasmic reticulum calcium ion homeostasis • transcription, DNA-templated • PML body organization • negative regulation of cell growth • intrinsic apoptotic signaling pathway by p53 class mediator • innate immune response • viral process • response to gamma radiation • response to UV • regulation of calcium ion transport into cytosol • positive regulation of protein localization to chromosome, telomeric region • fibroblast migration • protein targeting • immune system process • protein stabilization • positive regulation of apoptotic process involved in mammary gland involution • circadian regulation of gene expression • regulation of MHC class I biosynthetic process • negative regulation of viral release from host cell • regulation of circadian rhythm • negative regulation of interleukin-1 secretion • negative regulation of transcription, DNA-templated • maintenance of protein location in nucleus • cellular response to interleukin-4 • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • response to hypoxia • protein complex assembly • regulation of double-strand break repair • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • retinoic acid receptor signaling pathway • cell cycle arrest • negative regulation of angiogenesis • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • entrainment of circadian clock by photoperiod • negative regulation of mitotic cell cycle • positive regulation of MHC class I biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5371


18854

Ensembl


ENSG00000140464


ENSMUSG00000036986

UniProt


P29590


Q60953

RefSeq (mRNA)

NM_033250 NM_002675 NM_033238 NM_033239 NM_033240
NM_033244 NM_033246 NM_033247 NM_033249


NM_008884 NM_178087 NM_001311088

RefSeq (protein)

NP_002666 NP_150241 NP_150242 NP_150243 NP_150247
NP_150249 NP_150250 NP_150252 NP_150253

NP_001298017.1 NP_032910.3 NP_835188.2 NP_001298017 NP_032910
NP_835188

Location (UCSC)

Chr 15: 73.99 – 74.05 Mb

Chr 9: 58.22 – 58.25 Mb

PubMed search

1BOR, 2MVW, 2MWX, 4WJN, 4WJO

NM_033244
NM_033246
NM_033247
NM_033249

NM_008884
NM_178087
NM_001311088

NP_150249
NP_150250
NP_150252
NP_150253

...
Wikipedia