Programmed cell death 1

PDCD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M2D, 3RRQ, 4ZQK
Identifiers
Aliases	PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
External IDs	MGI: 104879 HomoloGene: 3681 GeneCards: PDCD1
Gene ontology Molecular function • protein binding • signal transducer activity Cellular component • integral component of membrane • plasma membrane • membrane • external side of plasma membrane Biological process • positive regulation of apoptotic process • multicellular organism development • T cell costimulation • negative regulation of apoptotic process • positive regulation of T cell apoptotic process • humoral immune response • negative regulation of tolerance induction • immune system process • apoptotic process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5133	18566
Ensembl	n/a	ENSMUSG00000026285
UniProt	Q15116	Q02242
RefSeq (mRNA)	NM_005018	NM_008798
RefSeq (protein)	NP_005009	NP_032824.1 NP_032824
Location (UCSC)	Chr 2: 241.85 – 241.86 Mb	Chr 1: 94.04 – 94.05 Mb
PubMed search

2M2D, 3RRQ, 4ZQK

5133

18566

n/a

ENSMUSG00000026285

Q15116

Q02242

NM_005018

NM_008798

NP_005009

NP_032824.1
NP_032824

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an immune checkpoint and guards against autoimmunity through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

A new class of drugs that block PD-1, the PD-1 inhibitors, activate the immune system to attack tumors and are therefore used with varying success to treat some types of cancer.

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Wikipedia