Priscillianism is a Christian belief system developed in the Iberian Peninsula (the Roman Hispania) in the 4th century by Priscillian, derived from the Gnostic-Manichaean doctrines taught by Marcus, an Egyptian from Memphis, and later considered a heresy by both the Eastern Orthodox Church and the Roman Catholic Church.
Marcus, a native of Memphis in Egypt, came to Spain and taught Gnostic and Manichean theories. Two of his followers, a Spanish lady named Agape and the rhetorician Helpidius, converted Priscillian, who was a layman "of noble birth, of great riches, bold, restless, eloquent, learned through much reading, very ready at debate and discussion". Through his oratorical gifts and reputation for extreme asceticism he attracted a large following, including a rhetorician named Helpidus and two bishops, Instantius and Salvianus. The new sect became an oath-bound society, attracting the attention of the bishop Hyginus of Cordoba. Hyginus made his fears known to Hydatius, Bishop of Emerita, and Ithacius of Ossonoba. The bishops of Hispania and Aquitaine then held a synod at Zaragoza in 380. Though summoned, the Priscillianists refused to appear, and the synod pronounced sentence of excommunication against the four leaders, Instantius, Salvianus, Helpidius and Priscillian.
Ithacius was chosen to enforce the synod's decrees, but he failed to bring the heretics to terms. In defiance Priscillian was ordained to the priesthood and appointed Bishop of Avila. Ithacius then appealed to the imperial authorities. The Emperor Gratian issued a decree which deprived the Priscillianists of their churches and sentenced them to exile. Instantius, Salvianus and Priscillian proceeded to Rome to gain the aid of Pope Damasus I (also from Iberia) in having this sentence revoked. On their journey they were joined by many supporters from Gaul. Euchrocia and her daughter Procula, amongst these, ministered of their substance to Priscillian and his colleagues. A promiscuous crowd of others, especially women, are mentioned. In consequence, injurious reports, probably calumnies, were vigorously circulated against Priscillian and his retinue.