Princess Marie of Schwarzburg-Rudolstadt (German: Prinzessin Marie von Schwarzburg-Rudolstadt; 29 January 1850 – 22 April 1922) was the consort and third wife of Frederick Francis II, Grand Duke of Mecklenburg-Schwerin. She was mother of Prince Hendrik, consort of Queen Wilhelmina of the Netherlands and father of Queen Juliana.

Princess Marie of Schwarzburg-Rudolstadt the first child of Prince Adolph of Schwarzburg-Rudolstadt, and his wife, Princess Mathilde of Schönburg-Waldenburg, was born at Raben Steinfeld, Mecklenburg-Schwerin. Her paternal great-grandfathers were Frederick Charles, Prince of Schwarzburg-Rudolstadt and Frederick V, Landgrave of Hesse-Homburg.

Her family belonged to the Principality of Schwarzburg-Rudolstadt

On 4 July 1868 in Rudolstadt, Schwarzburg-Rudolstadt, Marie married Frederick Francis II, Grand Duke of Mecklenburg-Schwerin, son of Paul Frederick, Grand Duke of Mecklenburg-Schwerin. Previously, Frederick Francis had been married twice: In 1849, he married Princess Augusta Reuss of Köstritz but she died in 1862. Two years later, Frederick Francis married secondly to Princess Anna of Hesse and by Rhine but less than a year after their marriage, Anna also died. At the time of the marriage, Frederick Francis was 45 and Marie 18. Together they had four children: