Luisa of Naples and Sicily (Luisa Maria Amalia Teresa; 27 July 1773 – 19 September 1802), was a Neapolitan and Sicilian princess and the wife of the third Habsburg Grand Duke of Tuscany.

Luisa Maria Amalia Teresa was born at the Royal Palace in Naples. Her father was the future King Ferdinand I of the Two Sicilies and her mother, born Maria Carolina of Austria, was a sister of Marie Antoinette. Her paternal grandparents were Charles III of Spain and his Saxon wife Maria Amalia; her maternal grandparents were Francis I, Holy Roman Emperor and Maria Theresa of Austria. She was one of eighteen children, seven of whom survived into adulthood.

On 15 August 1790, she married her double first cousin, Archduke Ferdinand of Austria. The wedding ceremony took place in Florence, the capital of the Grand Duchy of Tuscany which her husband had ruled since the beginning of the year. Her husband ruled the Grand Duchy till 1801, when in the Treaty of Aranjuez, he was forced by Napoleon to make way for the Kingdom of Etruria.

The couple went into exile and lived in Vienna, the capital of the Austrian Empire which was ruled by Archduke Ferdinand's older brother, Emperor Francis II; later on Ferdinand was compensated by being given the secularized lands of the Archbishop of Salzburg as Grand-Duke of Salzburg.

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