Princess Louise Caroline of Hesse-Kassel (German: Luise Karoline von Hessen-Kassel) (28 September 1789, Gottorp – 13 March 1867, Ballenstedt) was the consort of Friedrich Wilhelm, Duke of Schleswig-Holstein-Sonderburg-Glücksburg and the matriarch of the House of Schleswig-Holstein-Sonderburg-Glücksburg, which would eventually become the ruling house of the kingdoms of Denmark, Greece, Norway, and, barring unforeseen circumstances, the United Kingdom.

Louise Caroline was born at Gottorp in the Duchy of Schleswig to Landgrave Charles of Hesse-Kassel (19 December 1744 – 17 August 1836) and his wife Princess Louise of Denmark (30 January 1750 – 12 January 1831). Her elder sister Marie Sophie of Hesse-Kassel (28 October 1767 – 21 March 1852) became Queen consort of Frederick VI of Denmark.

Friedrich Wilhelm and Louise Caroline had ten children:

Louise Caroline's son, Prince Christian, was named third-in-line to the throne of Christian VIII of Denmark in 1847. He succeeded his childless cousin, Frederick VII of Denmark, on 15 November 1863, the Hereditary Prince Ferdinand having deceased somewhat earlier.

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