Joséphine de Lorraine (Marie Joséphine Thérèse; 26 August 1753 – 8 February 1797) was a princess of the House of Lorraine and by marriage the Princess of Carignan. She was the paternal grandmother of King Charles Albert of Sardinia, from whom the modern royal house of Italy descends.

Marie Joséphine Thérèse de Lorraine was the second of four children born to Louis de Lorraine, prince de Brionne, a cadet of the House of Guise, among the most influential families of France's ancien regime. The senior, sovereign branch of the House of Lorraine would merge with the Imperial House of Habsburg during her lifetime through marriage of the last reigning duke, Francis, to Maria Theresa of Austria. Her mother also belonged to a powerful family of princes étrangers, the House of Rohan. Her brother, Charles Eugène de Lorraine, prince de Lambesc (25 September 1751 – 11 November 1825), escorted his kinswoman Marie Antoinette to France from Vienna in 1770, became Austrian ambassador to France, and would be the last male of the Guise branch of the House of Lorraine.

On 18 October 1768 Joséphine married Prince Victor Amadeus of Savoy, the son and heir of Louis Victor, Prince of Carignan and his German wife, the Landgravine Christine Henriette of Hesse-Rotenburg. Amadeus was also the brother of the princesse de Lamballe, the tragic confidante of Queen Marie Antoinette.