Pregnancy-associated plasma protein A

PAPPA
Identifiers
Aliases	PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin 1
External IDs	OMIM: 176385 MGI: 97479 HomoloGene: 31097 GeneCards: PAPPA
Gene ontology Molecular function • zinc ion binding • peptidase activity • endopeptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • metalloendopeptidase activity Cellular component • extracellular region • extracellular space Biological process • cellular protein metabolic process • proteolysis • response to follicle-stimulating hormone • female pregnancy • response to glucocorticoid Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5069	18491
Ensembl	ENSG00000182752	ENSMUSG00000028370
UniProt	Q13219	Q8R4K8
RefSeq (mRNA)	NM_002581	NM_021362
RefSeq (protein)	NP_002572	NP_067337.1 NP_067337
Location (UCSC)	Chr 9: 116.15 – 116.4 Mb	Chr 4: 65.12 – 65.36 Mb
PubMed search

5069

18491

ENSG00000182752

ENSMUSG00000028370

Q13219

Q8R4K8

NM_002581

NM_021362

NP_002572

NP_067337.1
NP_067337

Pappalysin-1, also known as pregnancy-associated plasma protein A, is a protein encoded by the PAPPA gene in humans. PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome.

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). PAPPA's proteolytic function is activated upon collagen binding. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be commony seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

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Wikipedia