Polymorphous low grade adenocarcinoma

Polymorphous low-grade adenocarcinoma
Low magnification micrograph of a polymorphous low-grade adenocarcinoma, showing the typical variation of architectural arrangement. H&E stain.
Classification and external resources
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Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing malignant salivary gland tumor. It is most commonly found in the palate.

The name of the tumor derives from the fact that:

It affects the minor salivary glands in the area between the hard and the soft palate. Male to female ratio is 3:1, and the average age is 56 years.

PLGAs consist of a monomorphous cell population that has a varied histologic morphology.

Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma.

PLGAs are treated with wide local surgical excision and long-term follow-up. There is a recurrence rate of 14% (Peterson, contemporary of oral and maxillofacial surgery).

Polymorphous low-grade adenocarcinoma. H&E stain.

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