Polycystic kidney disease 2

PKD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KLD, 2KLE, 2KQ6, 2Y4Q, 3HRN, 3HRO
Identifiers
Aliases	PKD2, APC2, PKD4, Pc-2, TRPP2, Polycystic kidney disease 2, polycystin 2, transient receptor potential cation channel
External IDs	MGI: 1099818 HomoloGene: 20104 GeneCards: PKD2
Gene location (Human) Chr. Chromosome 4 (human) Band No data available Start 88,007,668 bp End 88,077,777 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 104,459,450 bp End 104,505,819 bp
Gene ontology Molecular function • ion channel binding • cytoskeletal protein binding • receptor binding • muscle alpha-actinin binding • metal ion binding • HLH domain binding • voltage-gated cation channel activity • protein homodimerization activity • calcium-induced calcium release activity • channel activity • protein binding • actinin binding • voltage-gated calcium channel activity • calcium channel activity • phosphoprotein binding • alpha-actinin binding • identical protein binding • ATPase binding • calcium ion binding • outward rectifier potassium channel activity • voltage-gated sodium channel activity • voltage-gated potassium channel activity • potassium channel activity • voltage-gated ion channel activity Cellular component • filamentous actin • membrane • integral component of cytoplasmic side of endoplasmic reticulum membrane • cell projection • extracellular exosome • lamellipodium • integral component of membrane • basal plasma membrane • integral component of lumenal side of endoplasmic reticulum membrane • ciliary membrane • polycystin complex • cilium • plasma membrane • cell-cell junction • ciliary basal body • endoplasmic reticulum • basal cortex • mitotic spindle • cytoplasm • motile cilium • non-motile cilium • integral component of plasma membrane • endoplasmic reticulum membrane • basolateral plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • regulation of calcium ion import • cellular response to osmotic stress • negative regulation of G1/S transition of mitotic cell cycle • heart looping • metanephric S-shaped body morphogenesis • negative regulation of cell proliferation • mesonephric tubule development • renal system development • metanephric cortex development • kidney development • cytoplasmic sequestering of transcription factor • ion transport • metanephric ascending thin limb development • branching involved in ureteric bud morphogenesis • neural tube development • spinal cord development • metanephric distal tubule development • centrosome duplication • cellular calcium ion homeostasis • determination of liver left/right asymmetry • cellular response to fluid shear stress • aorta development • cellular response to hydrostatic pressure • metanephric mesenchyme development • renal artery morphogenesis • metanephric cortical collecting duct development • mesonephric duct development • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • cellular response to reactive oxygen species • positive regulation of gene expression • metanephric part of ureteric bud development • regulation of cell proliferation • metanephric smooth muscle tissue development • positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell cycle arrest • heart development • JAK-STAT cascade • detection of mechanical stimulus • embryonic placenta development • detection of nodal flow • liver development • cell cycle arrest • regulation of cAMP metabolic process • placenta blood vessel development • renal tubule morphogenesis • determination of left/right symmetry • regulation of postsynaptic membrane potential • negative regulation of ryanodine-sensitive calcium-release channel activity • calcium ion transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • cellular response to calcium ion • sodium ion transmembrane transport • protein homotetramerization • cellular response to cAMP • potassium ion transmembrane transport • potassium ion transport • regulation of ion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5311	18764
Ensembl	ENSG00000118762	ENSMUSG00000034462
UniProt	Q13563	O35245
RefSeq (mRNA)	NM_000297	NM_008861
RefSeq (protein)	NP_000288	NP_032887
Location (UCSC)	Chr 4: 88.01 – 88.08 Mb	Chr 4: 104.46 – 104.51 Mb
PubMed search

2KLD, 2KLE, 2KQ6, 2Y4Q, 3HRN, 3HRO

5311

18764

ENSG00000118762

ENSMUSG00000034462

Q13563

O35245

NM_000297

NM_008861

NP_000288

NP_032887

Polycystin-2 is a protein that in humans is encoded by the PKD2 gene.

This gene encodes a member of the polycystin protein family, called TRPP2, previously known as polycystin-2, PC2 or APKD2. TRPP2 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1(TRPP1) to produce cation-permeable currents. It was discovered by Stefan Somlo at Yale University.

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