Plk1

PLK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34, 3P35, 3P36, 3P37, 3Q1I, 3RQ7, 3THB, 4A4L, 4A4O, 4DFW, 4E67, 4E9C, 4E9D, 4H5X, 4H71, 4HAB, 4HCO, 4HY2, 4J52, 4J53, 4LKL, 4LKM, 4O56, 4O6W, 4O9W, 4RCP, 4WHH, 4WHL, 4X9R, 4X9V, 4X9W, 2OGQ, 5J19
Identifiers
Aliases	PLK1, PLK, STPK13, polo like kinase 1
External IDs	MGI: 97621 HomoloGene: 3690 GeneCards: PLK1
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • microtubule binding • kinase activity • protein binding • anaphase-promoting complex binding • ATP binding • protein kinase binding • protein serine/threonine kinase activity Cellular component • cytoplasm • condensed nuclear chromosome, centromeric region • condensed chromosome kinetochore • cytosol • centrosome • spindle pole • microtubule cytoskeleton • spindle • condensed nuclear chromosome outer kinetochore • nucleoplasm • chromosome • microtubule organizing center • midbody • spindle microtubule • nucleolus • spindle midzone • chromatin • synaptonemal complex • chromosome, centromeric region • cytoskeleton • nucleus • kinetochore Biological process • centrosome organization • mitotic nuclear division • phosphorylation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • establishment of protein localization • synaptonemal complex disassembly • mitotic cytokinesis • negative regulation of apoptotic process • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • cytokinesis • G2 DNA damage checkpoint • homologous chromosome segregation • regulation of mitotic spindle assembly • mitotic spindle assembly checkpoint • regulation of cell cycle • cell division • protein phosphorylation • mitotic nuclear envelope disassembly • G2/M transition of mitotic cell cycle • positive regulation of peptidyl-threonine phosphorylation • peptidyl-serine phosphorylation • microtubule bundle formation • protein ubiquitination • protein destabilization • regulation of mitotic cell cycle • positive regulation of ubiquitin-protein transferase activity • positive regulation of proteolysis • mitotic sister chromatid segregation • regulation of mitotic metaphase/anaphase transition • cell cycle • anaphase-promoting complex-dependent catabolic process • cell proliferation • regulation of protein binding • protein localization to chromatin • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • female meiosis chromosome segregation • positive regulation of protein localization to nucleus • positive regulation of ubiquitin protein ligase activity • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • sister chromatid cohesion • regulation of cell cycle G2/M phase transition Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5347	18817
Ensembl	ENSG00000166851	ENSMUSG00000030867
UniProt	P53350	Q07832
RefSeq (mRNA)	NM_005030	NM_011121
RefSeq (protein)	NP_005021	NP_035251.3 NP_035251
Location (UCSC)	Chr 16: 23.68 – 23.69 Mb	Chr 7: 122.16 – 122.17 Mb
PubMed search

1Q4K, 1Q4O, 1UMW, 2OJX, 2OU7, 2OWB, 2RKU, 2V5Q, 2YAC, 3BZI, 3C5L, 3FVH, 3HIH, 3HIK, 3KB7, 3P2W, 3P2Z, 3P34, 3P35, 3P36, 3P37, 3Q1I, 3RQ7, 3THB, 4A4L, 4A4O, 4DFW, 4E67, 4E9C, 4E9D, 4H5X, 4H71, 4HAB, 4HCO, 4HY2, 4J52, 4J53, 4LKL, 4LKM, 4O56, 4O6W, 4O9W, 4RCP, 4WHH, 4WHL, 4X9R, 4X9V, 4X9W, 2OGQ, 5J19

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