Platelet factor 4

PF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Identifiers
Aliases	PF4, CXCL4, PF-4, SCYB4, platelet factor 4
External IDs	OMIM: 173460 MGI: 1888711 HomoloGene: 87791 GeneCards: PF4
Gene ontology Molecular function • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • protein binding Cellular component • extracellular region • platelet alpha granule lumen • extracellular space • cytoplasm • symbiont-containing vacuole membrane • other organism cytoplasm Biological process • G-protein coupled receptor signaling pathway • positive regulation of cAMP metabolic process • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • positive regulation of macrophage differentiation • platelet degranulation • negative regulation of megakaryocyte differentiation • positive regulation of cAMP-mediated signaling • negative regulation of MHC class II biosynthetic process • leukocyte chemotaxis • chemotaxis • response to lipopolysaccharide • positive regulation of macrophage derived foam cell differentiation • positive regulation of gene expression • regulation of cell proliferation • immune response • positive regulation of tumor necrosis factor production • negative regulation of angiogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • inflammatory response • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cytolysis • platelet activation • defense response • positive regulation of neutrophil chemotaxis • killing of cells of other organism • defense response to protozoan • killing by host of symbiont cells • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5196	56744
Ensembl	ENSG00000163737	ENSMUSG00000029373
UniProt	P02776	Q9Z126
RefSeq (mRNA)	NM_002619	NM_019932
RefSeq (protein)	NP_002610	NP_064316.1 NP_064316
Location (UCSC)	Chr 4: 73.98 – 73.98 Mb	Chr 5: 90.77 – 90.77 Mb
PubMed search

1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU

5196

56744

ENSG00000163737

ENSMUSG00000029373

P02776

Q9Z126

NM_002619

NM_019932

NP_002610

NP_064316.1
NP_064316

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.

...
Wikipedia