Plasminogen activator inhibitor-1

SERPINE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 9PAI, 5BRR,%%s1C5G
Identifiers
Aliases	SERPINE1, PAI, PAI-1, PAI1, PLANH1, serpin family E member 1
External IDs	MGI: 97608 HomoloGene: 68070 GeneCards: SERPINE1
Gene ontology Molecular function • peptidase inhibitor activity • protease binding • protein binding • receptor binding • serine-type endopeptidase inhibitor activity Cellular component • extracellular matrix • plasma membrane • extracellular exosome • platelet alpha granule lumen • extracellular region • extracellular space Biological process • negative regulation of endothelial cell apoptotic process • positive regulation of receptor-mediated endocytosis • negative regulation of peptidase activity • negative regulation of fibrinolysis • positive regulation of inflammatory response • negative regulation of plasminogen activation • fibrinolysis • negative regulation of smooth muscle cell-matrix adhesion • negative regulation of blood coagulation • negative regulation of vascular wound healing • regulation of receptor activity • negative regulation of smooth muscle cell migration • positive regulation of monocyte chemotaxis • platelet degranulation • extracellular matrix organization • positive regulation of angiogenesis • negative regulation of cell migration • chronological cell aging • positive regulation of blood coagulation • defense response to Gram-negative bacterium • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • circadian rhythm • angiogenesis • positive regulation of interleukin-8 production • negative regulation of wound healing • cellular response to lipopolysaccharide • negative regulation of cell adhesion mediated by integrin • negative regulation of endopeptidase activity • positive regulation of transcription from RNA polymerase II promoter • positive regulation of leukotriene production involved in inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5054	18787
Ensembl	ENSG00000106366	ENSMUSG00000037411
UniProt	P05121	P22777
RefSeq (mRNA)	NM_001165413 NM_000602	NM_008871
RefSeq (protein)	NP_000593 NP_000593.1	NP_032897
Location (UCSC)	Chr 7: 101.13 – 101.14 Mb	Chr 5: 137.06 – 137.07 Mb
PubMed search

1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 9PAI, 5BRR,%%s1C5G

5054

18787

ENSG00000106366

...
Wikipedia