Pitrilysin metallopeptidase 1

PITRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L3T, 4NGE, 4RPU
Identifiers
Aliases	PITRM1, MP1, PreP, pitrilysin metallopeptidase 1
External IDs	MGI: 1916867 HomoloGene: 5742 GeneCards: PITRM1
Gene location (Human) Chr. Chromosome 10 (human) Band n/a Start 3,137,728 bp End 3,172,841 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 6,548,149 bp End 6,580,515 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • enzyme activator activity • metalloendopeptidase activity • catalytic activity • hydrolase activity • metallopeptidase activity • metal ion binding Cellular component • mitochondrial matrix • mitochondrion Biological process • proteolysis • positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10531	69617
Ensembl	ENSG00000107959	ENSMUSG00000021193
UniProt	Q5JRX3	Q8K411
RefSeq (mRNA)	NM_001242307 NM_001242309 NM_014889 NM_014968 NM_001347725 NM_001347726 NM_001347727 NM_001347728 NM_001347729 NM_001347730	NM_145131
RefSeq (protein)	NP_001229236 NP_001229238 NP_001334654 NP_001334655 NP_001334656 NP_001334657 NP_001334658 NP_001334659 NP_055704	NP_660113
Location (UCSC)	Chr 10: 3.14 – 3.17 Mb	Chr 10: 6.55 – 6.58 Mb
PubMed search

4L3T, 4NGE, 4RPU

10531

69617

ENSG00000107959

ENSMUSG00000021193

Q5JRX3

Q8K411

NM_001347726
NM_001347727
NM_001347728
NM_001347729
NM_001347730

NM_145131

NP_001334657
NP_001334658
NP_001334659
NP_055704

NP_660113

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene. It is also sometimes called metalloprotease 1 (MP1).PreP facilitates proteostasis by utilizing an ~13300-A(3) catalytic chamber to degrade toxic peptides, including mitochondrial presequences and β-amyloid. Deficiency of PreP is found associated with Alzheimer’s disease.

...
Wikipedia