Phosducin

PDC
Identifiers
Aliases	PDC, MEKA, PHD, PhLOP, PhLP, phosducin
External IDs	MGI: 98090 HomoloGene: 1950 GeneCards: PDC
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.1 Start 186,443,566 bp End 186,461,122 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 G1|1 63.84 cM Start 150,319,417 bp End 150,333,906 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • phospholipase inhibitor activity • queuine tRNA-ribosyltransferase activity Cellular component • photoreceptor inner segment • cytoplasm • cytosol • photoreceptor outer segment • cell projection • Butt • nucleus Biological process • queuosine biosynthetic process • G-protein coupled receptor signaling pathway • response to stimulus • visual perception • phototransduction • negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5132	20028
Ensembl	ENSG00000116703	ENSMUSG00000006007
UniProt	P20941 Q52LP8	Q9QW08
RefSeq (mRNA)	NM_002597 NM_022576 NM_022577	NM_001159730 NM_024458
RefSeq (protein)	NP_002588 NP_072098 NP_002588.3	NP_001153202 NP_077778
Location (UCSC)	Chr 1: 186.44 – 186.46 Mb	Chr 1: 150.32 – 150.33 Mb
PubMed search

5132

20028

ENSG00000116703

ENSMUSG00000006007

P20941
Q52LP8

Q9QW08

NM_002597
NM_022576
NM_022577

NM_001159730
NM_024458

NP_002588
NP_072098
NP_002588.3

NP_001153202
NP_077778

Phosducin, also known as PDC, is a human protein and gene. It belongs to phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the Transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

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Wikipedia