Peter Propping
| Peter Propping | |
|---|---|
| Born | 1 December 1942 Berlin |
| Died | 26 April 2016 (aged 73) |
| Residence | Germany |
| Nationality | German |
| Fields | Genetics |
| Institutions | University of Bonn |
| Known for | alcoholism, manic depressive disorders, schizophrenia, epilepsy, and hereditary cancer predispositions |
Peter Propping (21 December 1942 – 26 April 2016) was a German Human geneticist.
The scientific work of Propping spans genetically complex diseases, especially affecting brain function such as alcoholism, manic depressive disorders, schizophrenia, epilepsy, and in addition hereditary cancer predispositions. He also studied the history of human genetics and eugenics. From 1984 to 2008 he was director of the Institute of Human Genetics of the University of Bonn.
Peter Propping studied medicine at the Free University of Berlin from 1962 to 68, receiving his MD degree in 1970 based on experimental work in pharmacology. After having received his license to practise medicine he became a research assistant at the Institute of Anthropology and Human Genetics of the University of Heidelberg. From 1980 to 83 Propping was a Heisenberg fellow for psychiatric genetics of the German Research Council. During this time he worked both at the Central Institute of Menthal Health in Mannheim and at the Institute of Anthropology and Human Genetics of the University of Heidelberg. From 1984 to 2008 Propping was a full professor of human genetics and director of the Institute of Human Genetics of the University of Bonn. He was dean of the faculty of medicine from 1990 to 1992, and vice rector for research of the University of Bonn from 1994 to 96. In 1995 he received the newly introduced recognition as a specialist in human genetics by the German Medical Association. From 1991 to 97 he coordinated the research programme on "Genetic factors in psychiatric disorders" of the German Research Council, and from 1996 to 2004 he was speaker of the graduate college "Pathogenesis of disorders of the central nervous system". From 1999 to 2012 Propping coordinated the German HNPCC consortium supported by the German Cancer Aid. From 2006 to 08 he chaired the German Society of Human Genetics. After becoming an emeritus in 2008 he was named Senior Professor by the rector of the University of Bonn.
Propping could show that the intra-animal culture of bacteria (host-mediated assay) designed to induce mutations by chemical agents reflects the metabolism of the host. He also compiled findings reported in the literature that point to the genetic influence on drug effects on brain function. In a large twin study and in carriers of the normal electroencephalogram (EEG) he could show that the effect of ethanol on the EEG is strongly influenced by genetic factors. In addition, the metabolism of alcohol is under genetic control. In Bonn, Propping initiated a long term study in order to analyse the genetic contribution to manic depression. In contrast to the expectation that was widespread among researchers it was not possible to pin down genetic factors through the linkage approach. In rare forms of epilepsy, however, mutated genes could be uncovered through positional cloning. Propping was also involved in large international studies that made use of the method of genome-wide association analysis (GWAS). It turned out that there exists a genetic overlap between various mental disorders. In familial adenomatous polyposis Propping and his research group could refine the genotype-phenotype-relationship. In the most frequent form of inherited colorectal cancer (HNPCC, Lynch syndrome) Propping's group could define several relationships between genotype and phenotype that play a role for genetic transmission, diagnostics, prognosis, and cancer prevention.
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