Pericentrin

PCNT

Identifiers

PCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin

External IDs

Gene ontology
Molecular function	• protein binding • calmodulin binding
Cellular component	• centriole • centrosome • centriolar satellite • microtubule • membrane • cytoskeleton • cytoplasm • microtubule organizing center • cytosol
Biological process	• positive regulation of intracellular protein transport • mitotic spindle organization • G2/M transition of mitotic cell cycle • microtubule cytoskeleton organization • cilium morphogenesis • ciliary basal body docking
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5116


n/a


ENSG00000160299


n/a


O95613


n/a

RefSeq (mRNA)


NM_006031 NM_001315529


n/a

RefSeq (protein)


NP_001302458 NP_006022


n/a

Location (UCSC)

n/a

PubMed search

n/a

n/a

n/a

n/a

n/a

n/a

Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix(PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.

PCNT is a 360 kDa protein which contains a series of coiled coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The PACT domain is responsible for targeting the protein to the centrosomes and attaching it to the centriole walls during interphase. In addition, PCNT possesses five nuclear export sequences which all contribute to its nuclear export into the cytoplasm, as well as one nuclear localization signal composed of three clusters of basic amino acids, all of which contribute to the protein’s nuclear localization.