Periannan Senapathy
| Periannan Senapathy | |
|---|---|
| Born |
Periannan Senapathy Chennai, Tamil Nadu, India |
| Alma mater |
National Institutes of Health University of Wisconsin, Madison Indian Institute of Science |
| Known for |
Genomics Evolution |
| Website | Genome International Corporation |
| Scientific career | |
| Institutions | Genome International Corporation |
Periannan Senapathy is a molecular biologist, geneticist, author and entrepreneur. He is the founder, president and chief scientific officer at Genome International Corporation, a biotechnology & bioinformatics firm based in Madison, Wisconsin, which develops next-generation DNA sequencing analysis technologies.
Senapathy is known for his contributions in the biology of RNA splicing and the structure of eukaryotic genes. An algorithm developed by him, known as Shapiro & Senapathy algorithm (S&S) for predicting the splice sites, exons and genes in any animal or plant, has the ability to discover disease-causing mutations in splice junctions in numerous cancers and non-cancer diseases. The Shapiro - Senapathy algorithm has been implemented in many gene-finding and mutation detection tools, and is being used in major research institutions around the world for uncovering mutations in the splicing regions. It is increasingly used in the Next Generation Sequencing era, as it is widely realized that >60% of all mutations causing diseases or adverse drug reactions in humans and other animals occur within the splicing regions of genes. The S&S algorithm has been cited in ~3,000 publications on finding splicing mutations in thousands of diseases including many different forms of cancer.
Senapathy is also known for offering a new theory on the origin and diversity of life on earth, where he proposes that genomes for eukaryotic life forms could have been directly assembled from a common pool of split genes in prebiotic chemistry. He had authored a book, titled Independent Birth of Organisms in 1994, where he first proposed this theory. He has also published his scientific findings in journals such as Science (journal), Nucleic Acids Research, PNAS among others, and is the author of several patents in the genomics field.
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