Perforin

PRF1
Identifiers
Aliases	PRF1, FLH2, HPLH2, P1, PFN1, PFP, perforin 1
External IDs	OMIM: 170280 MGI: 97551 HomoloGene: 3698 GeneCards: PRF1
Gene ontology Molecular function • protein binding • metal ion binding • calcium ion binding • wide pore channel activity Cellular component • integral component of membrane • extracellular region • endosome • plasma membrane • endosome lumen • membrane • cytosol • cytolytic granule Biological process • cellular defense response • immunological synapse formation • cytolysis • apoptotic process • transmembrane transport • defense response to tumor cell • immune response to tumor cell • protein homooligomerization • defense response to virus • positive regulation of killing of cells of other organism Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5551	18646
Ensembl	ENSG00000180644	ENSMUSG00000037202
UniProt	P14222	P10820
RefSeq (mRNA)	NM_005041 NM_001083116	NM_011073
RefSeq (protein)	NP_001076585 NP_005032	NP_035203.3 NP_035203
Location (UCSC)	Chr 10: 70.6 – 70.6 Mb	Chr 10: 61.3 – 61.3 Mb
PubMed search

5551

18646

ENSG00000180644

ENSMUSG00000037202

P14222

P10820

NM_005041
NM_001083116

NM_011073

NP_001076585
NP_005032

NP_035203.3
NP_035203

Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.

Perforin is a pore forming cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin binds to the target cell's plasma membrane, and oligomerises in a Ca2+ dependent manner to form pores on the target cell. The pore formed allows for the passive diffusion of a family of pro-apoptotic proteases, known as the granzymes, into the target cell. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.

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Wikipedia