Peptide YY

PYY
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L60, 2DEZ, 2DF0
Identifiers
Aliases	PYY, PYY-I, PYY1, peptide YY
External IDs	OMIM: 600781 MGI: 99924 HomoloGene: 3066 GeneCards: PYY
Gene ontology Molecular function • neuropeptide hormone activity • protein binding • G-protein coupled receptor binding • hormone activity Cellular component • extracellular region • extracellular space Biological process • G-protein coupled receptor signaling pathway • cell-cell signaling • digestion • movement of cell or subcellular component • regulation of appetite • cell proliferation • neuropeptide signaling pathway • cytoskeleton organization • eating behavior • feeding behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5697	217212
Ensembl	ENSG00000131096	ENSMUSG00000017311
UniProt	P10082	Q9EPS2
RefSeq (mRNA)	NM_004160	NM_145435 NM_001346771
RefSeq (protein)	NP_004151	NP_663410.1 NP_001333700 NP_663410
Location (UCSC)	Chr 17: 43.95 – 44 Mb	Chr 11: 102.11 – 102.11 Mb
PubMed search

2L60, 2DEZ, 2DF0

5697

217212

ENSG00000131096

ENSMUSG00000017311

P10082

Q9EPS2

NM_004160

NM_145435
NM_001346771

NP_004151

NP_663410.1
NP_001333700
NP_663410

Peptide YY (PYY) also known as peptide tyrosine tyrosine or pancreatic peptide YY_3-36 is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite.

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