Pax-6

PAX6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CUE, 6PAX

Identifiers

Aliases

PAX6, AN, AN2, D11S812E, FVH1, MGDA, WAGR, paired box 6, ASGD5

External IDs

OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6

Gene ontology
Molecular function	• protein binding • DNA binding • sequence-specific DNA binding • ubiquitin-protein transferase activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • protein kinase binding • ubiquitin protein ligase binding • histone acetyltransferase binding • transcription regulatory region DNA binding • co-SMAD binding • R-SMAD binding • HMG box domain binding
Cellular component	• cytoplasm • nucleus • nucleoplasm • cytosol • nuclear chromatin • intracellular
Biological process	• eye development • blood vessel development • animal organ morphogenesis • regulation of transcription, DNA-templated • glucose homeostasis • transcription, DNA-templated • central nervous system development • response to wounding • cell differentiation • cornea development in camera-type eye • negative regulation of neurogenesis • visual perception • iris morphogenesis • multicellular organism development • neuron fate commitment • protein ubiquitination • negative regulation of transcription from RNA polymerase II promoter • establishment of mitotic spindle orientation • cell fate determination • neuron migration • negative regulation of protein phosphorylation • positive regulation of neuroblast proliferation • lens development in camera-type eye • regionalization • type B pancreatic cell differentiation • pancreatic A cell development • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • smoothened signaling pathway • axonogenesis • axon guidance • brain development • salivary gland morphogenesis • negative regulation of cell proliferation • regulation of asymmetric cell division • dorsal/ventral axis specification • anterior/posterior pattern specification • dorsal/ventral pattern formation • regulation of gene expression • positive regulation of gene expression • pallium development • oligodendrocyte cell fate specification • cerebral cortex regionalization • forebrain dorsal/ventral pattern formation • commitment of neuronal cell to specific neuron type in forebrain • forebrain-midbrain boundary formation • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment • telencephalon regionalization • pituitary gland development • habenula development • signal transduction involved in regulation of gene expression • keratinocyte differentiation • regulation of cell migration • positive regulation of epithelial cell differentiation • forebrain development • lacrimal gland development • protein localization to organelle • eye photoreceptor cell development • camera-type eye development • cell fate commitment • negative regulation of neuron differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of timing of cell differentiation • embryonic camera-type eye morphogenesis • astrocyte differentiation • negative regulation of epithelial cell proliferation • regulation of neurogenesis • retina development in camera-type eye • cellular response to leukemia inhibitory factor • negative regulation of neural precursor cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5080


18508

Ensembl


ENSG00000007372


ENSMUSG00000027168

UniProt


P26367


P63015

RefSeq (mRNA)

NM_000280 NM_001127612 NM_001258462 NM_001258463 NM_001258464
NM_001258465 NM_001310158 NM_001310159 NM_001310160 NM_001310161 NM_001604

NM_001244198 NM_001244200 NM_001244201 NM_001244202 NM_013627
NM_001310144 NM_001310145 NM_001310146

RefSeq (protein)

NP_000271 NP_001121084 NP_001245391 NP_001245392 NP_001245393
NP_001245394 NP_001297087 NP_001297088 NP_001297089 NP_001297090 NP_001595

NP_001231127 NP_001231129 NP_001231130 NP_001231131 NP_001297073
NP_001297074 NP_001297075 NP_038655

Location (UCSC)

Chr 11: 31.78 – 31.82 Mb

Chr 2: 105.67 – 105.7 Mb

PubMed search

NM_001258465
NM_001310158
NM_001310159
NM_001310160
NM_001310161
NM_001604

NM_001310144
NM_001310145
NM_001310146

NP_001245394
NP_001297087
NP_001297088
NP_001297089
NP_001297090
NP_001595

...
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