Paolo Emilio Cesi (1481–1537) was an Italian Roman Catholic cardinal.
Paolo Emilio Cesi was born in Umbria in 1481. One of twelve children born to Roman noble Angelo Cesi and Francesca Cardoli. His younger brother, Federico Cesi, also became a cardinal. After finishing school, he moved to Rome where he served as a notary at the Fifth Council of the Lateran, a canon of Santa Maria Maggiore, a protonotary apostolic, and a regent of the Chancery of Apostolic Briefs.
He was named cardinal deacon by Pope Leo X in the consistory of July 1, 1517. On July 6, 1517, he received the red hat and the deaconry of San Nicola in Carcere. He participated in the papal conclave of 1521-22 that elected Pope Adrian VI.
He was the administrator of the see of Lund from February 6, 1520 to July 12, 1521; administrator of the see of Sion from November 12, 1522 until September 8, 1529; and administrator of the see of Todi from June 1, 1523 until he resigned in favor of his brother Federico. Pope Adrian VI named him one of the judges in the case against Cardinal Francesco Soderini.