PYCR1

PYCR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GER, 2GR9, 2GRA, 2IZZ
Identifiers
Aliases	PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR, pyrroline-5-carboxylate reductase 1
External IDs	MGI: 2384795 HomoloGene: 56002 GeneCards: PYCR1
Gene ontology Molecular function • oxidoreductase activity • protein binding • pyrroline-5-carboxylate reductase activity • identical protein binding Cellular component • mitochondrial matrix • mitochondrion Biological process • regulation of mitochondrial membrane potential • cellular response to oxidative stress • negative regulation of hydrogen peroxide-induced cell death • cellular amino acid biosynthetic process • oxidation-reduction process • L-proline biosynthetic process • proline biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5831	209027
Ensembl	ENSG00000183010	ENSMUSG00000025140
UniProt	P32322	Q922W5
RefSeq (mRNA)	NM_001282279 NM_001282280 NM_001282281 NM_006907 NM_153824 NM_001330523	NM_144795 NM_001348222
RefSeq (protein)	NP_001269208 NP_001269209 NP_001269210 NP_001317452 NP_008838 NP_722546	NP_659044.1 NP_659044
Location (UCSC)	Chr 17: 81.93 – 81.94 Mb	Chr 11: 120.64 – 120.64 Mb
PubMed search

2GER, 2GR9, 2GRA, 2IZZ

5831

209027

ENSG00000183010

ENSMUSG00000025140

P32322

Q922W5

NM_001330523

NM_144795
NM_001348222

NP_722546

NP_659044.1
NP_659044

Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene.

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.

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