PVRL2

NECTIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	MGI: 97822 HomoloGene: 86092 GeneCards: NECTIN2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 44,846,175 bp End 44,889,228 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.94 cM Start 19,716,644 bp End 19,750,483 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • coreceptor activity • virus receptor activity • protein binding • identical protein binding • receptor binding • cell adhesion molecule binding • protein heterodimerization activity • protein homodimerization activity Cellular component • integral component of membrane • membrane • cell-cell junction • focal adhesion • plasma membrane • integral component of plasma membrane • cell-cell adherens junction • cell surface • zonula adherens • extracellular exosome • apical junction complex • cell-cell contact zone Biological process • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • sperm mitochondrion organization • cell recognition • positive regulation of immunoglobulin mediated immune response • regulation of viral entry into host cell • susceptibility to natural killer cell mediated cytotoxicity • positive regulation of mast cell activation • cell adhesion • acrosome assembly • cytoskeleton organization • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • cilium organization • establishment of mitochondrion localization • spermatid development • regulation of immune response • fertilization • spermatid nucleus differentiation • susceptibility to T cell mediated cytotoxicity • viral process • cell part morphogenesis • adherens junction organization • positive regulation of natural killer cell mediated cytotoxicity • homophilic cell adhesion via plasma membrane adhesion molecules • viral entry into host cell • signal transduction • positive regulation of T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5819	19294
Ensembl	ENSG00000130202	ENSMUSG00000062300
UniProt	Q92692	P32507
RefSeq (mRNA)	NM_001042724 NM_002856	NM_001159724 NM_008990
RefSeq (protein)	NP_001036189 NP_002847	NP_001153196 NP_033016
Location (UCSC)	Chr 19: 44.85 – 44.89 Mb	Chr 19: 19.72 – 19.75 Mb
PubMed search

3R0N, 4DFH, 4DFI, 4HZA

5819

19294

ENSG00000130202

ENSMUSG00000062300

Q92692

P32507

NM_001042724
NM_002856

NM_001159724
NM_008990

NP_001036189
NP_002847

NP_001153196
NP_033016

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.

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