PTX3

PTX3
Identifiers
Aliases	PTX3, TNFAIP5, TSG-14, pentraxin 3
External IDs	MGI: 104641 HomoloGene: 7500 GeneCards: PTX3
Gene ontology Molecular function • (1->3)-beta-D-glucan binding • virion binding • complement component C1q binding • protein binding • identical protein binding Cellular component • extracellular region • extracellular space • specific granule lumen • tertiary granule lumen Biological process • positive regulation of nitric oxide biosynthetic process • negative regulation of glycoprotein metabolic process • positive regulation of phagocytosis • negative regulation of exo-alpha-sialidase activity • response to yeast • negative regulation by host of viral exo-alpha-sialidase activity • negative regulation by host of viral glycoprotein metabolic process • innate immune response • inflammatory response • negative regulation of viral entry into host cell • opsonization • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5806	19288
Ensembl	ENSG00000163661	ENSMUSG00000027832
UniProt	P26022	P48759
RefSeq (mRNA)	NM_002852	NM_008987
RefSeq (protein)	NP_002843	NP_033013
Location (UCSC)	Chr 3: 157.44 – 157.44 Mb	Chr 3: 66.22 – 66.23 Mb
PubMed search

5806

19288

ENSG00000163661

ENSMUSG00000027832

P26022

P48759

NM_002852

NM_008987

NP_002843

NP_033013

Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene.

Pentraxin 3 (ptx3) is a member of the pentraxin superfamily. This super family characterized by cyclic multimeric structure. PTX3 is rapidly produced and released by several cell types, in particular by mononuclear phagocytes, dendritic cells (DCs), fibroblasts and endothelial cells in response to primary inflammatory signals [e.g., toll-like receptor (TLR) engagement, TNFα, IL-1β]. PTX3 binds with high affinity to the complement component C1q, the extracellular matrix component TNFα induced protein 6 (TNFAIP6; also called TNF-stimulated gene 6, TSG-6) and selected microorganisms, including Aspergillus fumigatus and Pseudomonas aeruginosa. PTX3 activates the classical pathway of complement activation and facilitates pathogen recognition by macrophages and DCs.

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