PTPN11

PTPN11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG, 4RDD, 4QSY, 5DF6, 5IBS, 5EHP, 5EHR, 5I6V, 5IBM
Identifiers
Aliases	PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11
External IDs	OMIM: 176876 MGI: 99511 HomoloGene: 2122 GeneCards: PTPN11
Gene ontology Molecular function • phospholipase binding • phosphoprotein phosphatase activity • insulin receptor binding • protein domain specific binding • phosphatase activity • receptor tyrosine kinase binding • peptide hormone receptor binding • protein binding • non-membrane spanning protein tyrosine phosphatase activity • protein tyrosine phosphatase activity • insulin receptor substrate binding • D1 dopamine receptor binding • hydrolase activity • SH3/SH2 adaptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • cell adhesion molecule binding • protein tyrosine kinase binding Cellular component • cytoplasm • cytosol • protein complex • mitochondrion • nucleus Biological process • dephosphorylation • megakaryocyte development • positive regulation of signal transduction • negative regulation of insulin secretion • regulation of cell adhesion mediated by integrin • atrioventricular canal development • intestinal epithelial cell migration • organ growth • epidermal growth factor receptor signaling pathway • negative regulation of growth hormone secretion • axonogenesis • glucose homeostasis • regulation of protein export from nucleus • multicellular organism growth • regulation of multicellular organism growth • lipid metabolic process • ephrin receptor signaling pathway • abortive mitotic cell cycle • DNA damage checkpoint • protein dephosphorylation • T cell costimulation • platelet formation • microvillus organization • positive regulation of mitotic cell cycle • positive regulation of glucose import in response to insulin stimulus • genitalia development • platelet activation • fibroblast growth factor receptor signaling pathway • heart development • brain development • regulation of type I interferon-mediated signaling pathway • activation of MAPK activity • hormone-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • integrin-mediated signaling pathway • Bergmann glial cell differentiation • homeostasis of number of cells within a tissue • inner ear development • platelet-derived growth factor receptor signaling pathway • negative regulation of cortisol secretion • peptidyl-tyrosine dephosphorylation • ERBB signaling pathway • negative regulation of hormone secretion • triglyceride metabolic process • hormone metabolic process • positive regulation of hormone secretion • negative regulation of cell adhesion mediated by integrin • regulation of protein complex assembly • face morphogenesis • cerebellar cortex formation • phosphatidylinositol-mediated signaling • leukocyte migration • multicellular organismal reproductive process • phosphatidylinositol phosphorylation • neurotrophin TRK receptor signaling pathway • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • cellular response to mechanical stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5781	19247
Ensembl	ENSG00000179295	ENSMUSG00000043733
UniProt	Q06124	P35235
RefSeq (mRNA)	NM_002834 NM_080601 NM_001330437	NM_001109992 NM_011202
RefSeq (protein)	NP_001317366 NP_002825 NP_542168	NP_001103462.1 NP_035332.1 NP_001103462 NP_035332
Location (UCSC)	Chr 12: 112.42 – 112.51 Mb	Chr 5: 121.13 – 121.19 Mb
PubMed search

2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG, 4RDD, 4QSY, 5DF6, 5IBS, 5EHP, 5EHR, 5I6V, 5IBM

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