PTK2B

PTK2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LK4, 3CC6, 3ET7, 3FZO, 3FZP, 3FZR, 3FZS, 3FZT, 3GM1, 3GM2, 3GM3, 3H3C, 3U3F, 4EKU, 4H1J, 4H1M, 4R32, 4XEK, 4XEF, 4XEV
Identifiers
Aliases	PTK2B, CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK, protein tyrosine kinase 2 beta
External IDs	MGI: 104908 HomoloGene: 23001 GeneCards: PTK2B
Gene ontology Molecular function • protein complex binding • kinase activity • receptor binding • ATP binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • transferase activity • protein binding • nucleotide binding • 3-phosphoinositide-dependent protein kinase binding • NMDA glutamate receptor activity • signal transducer activity • calmodulin-dependent protein kinase activity • enzyme binding • protein tyrosine kinase activity • ubiquitin protein ligase binding Cellular component • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • NMDA selective glutamate receptor complex • perinuclear region of cytoplasm • cytoskeleton • nucleus • cell projection • membrane raft • lamellipodium • apical dendrite • growth cone • plasma membrane • axon • neuronal cell body • cell cortex • cell body • postsynaptic density • cell junction • dendrite • cytosol • cytoplasm • dendritic spine Biological process • negative regulation of neuron apoptotic process • cellular response to retinoic acid • adaptive immune response • positive regulation of actin filament polymerization • tumor necrosis factor-mediated signaling pathway • positive regulation of JNK cascade • regulation of angiogenesis • marginal zone B cell differentiation • negative regulation of muscle cell apoptotic process • positive regulation of translation • stress fiber assembly • negative regulation of ossification • protein phosphorylation • cell surface receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • regulation of cell adhesion • positive regulation of reactive oxygen species metabolic process • angiogenesis • positive regulation of ERK1 and ERK2 cascade • long term synaptic depression • positive regulation of excitatory postsynaptic potential • regulation of cGMP-mediated signaling • response to ethanol • neuron projection development • negative regulation of cell proliferation • response to cocaine • apoptotic process • regulation of actin cytoskeleton reorganization • positive regulation of cellular protein metabolic process • epidermal growth factor receptor signaling pathway • actin filament organization • response to reactive oxygen species • chemokine-mediated signaling pathway • response to mechanical stimulus • signal complex assembly • bone resorption • response to lithium ion • response to osmotic stress • positive regulation of cell growth • positive regulation of nitric-oxide synthase activity • positive regulation of synaptic transmission, glutamatergic • ionotropic glutamate receptor signaling pathway • response to organonitrogen compound • positive regulation of DNA biosynthetic process • positive regulation of peptidyl-tyrosine phosphorylation • protein autophosphorylation • innate immune response • negative regulation of myeloid cell differentiation • response to immobilization stress • cell differentiation • phosphorylation • positive regulation of cell-matrix adhesion • positive regulation of JUN kinase activity • immune system process • regulation of release of sequestered calcium ion into cytosol • negative regulation of apoptotic process • sprouting angiogenesis • regulation of inositol trisphosphate biosynthetic process • response to glucose • cellular response to fluid shear stress • positive regulation of angiogenesis • response to calcium ion • regulation of NMDA receptor activity • cellular defense response • oocyte maturation • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of potassium ion transport • regulation of cell shape • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • positive regulation of B cell chemotaxis • response to hormone • response to cAMP • regulation of nitric oxide biosynthetic process • regulation of establishment of cell polarity • response to hydrogen peroxide • regulation of macrophage chemotaxis • positive regulation of protein kinase activity • regulation of leukocyte chemotaxis • negative regulation of bone mineralization • regulation of cell migration • response to hypoxia • protein complex assembly • blood vessel endothelial cell migration • activation of GTPase activity • positive regulation of cell migration • regulation of bone mineralization • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • response to stress • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of endothelial cell migration • focal adhesion assembly • regulation of cell proliferation • regulation of cGMP biosynthetic process • regulation of calcium-mediated signaling • positive regulation of cell proliferation • positive regulation of neuron projection development • glial cell proliferation • activation of Janus kinase activity • peptidyl-tyrosine phosphorylation • regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • response to drug • signal transduction • long-term synaptic potentiation • cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2185	19229
Ensembl	ENSG00000120899	ENSMUSG00000059456
UniProt	Q14289	Q9QVP9
RefSeq (mRNA)	NM_004103 NM_173174 NM_173175 NM_173176	NM_001162365 NM_001162366 NM_172498
RefSeq (protein)	NP_004094 NP_775266 NP_775267 NP_775268	NP_001155838.1 NP_001155837 NP_001155838 NP_766086
Location (UCSC)	Chr 8: 27.31 – 27.46 Mb	Chr 14: 66.15 – 66.28 Mb
PubMed search

2LK4, 3CC6, 3ET7, 3FZO, 3FZP, 3FZR, 3FZS, 3FZT, 3GM1, 3GM2, 3GM3, 3H3C, 3U3F, 4EKU, 4H1J, 4H1M, 4R32, 4XEK, 4XEF, 4XEV

2185

19229

ENSG00000120899

ENSMUSG00000059456

...
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