PTEN (gene)

PTEN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ

Identifiers

Aliases

PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog

External IDs

OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • PDZ domain binding • phosphatase activity • enzyme binding • magnesium ion binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • platelet-derived growth factor receptor binding • protein binding • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • identical protein binding • hydrolase activity • lipid binding • ubiquitin-specific protease binding
Cellular component	• cytoplasm • postsynaptic membrane • extracellular region • mitochondrion • neuron projection • cytoplasmic side of plasma membrane • nucleus • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • apical plasma membrane • plasma membrane • PML body • nucleoplasm • cytosol
Biological process	• multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • long term synaptic depression • positive regulation of excitatory postsynaptic potential • cell proliferation • response to ethanol • neuron projection development • cellular response to hypoxia • negative regulation of cell size • negative regulation of cell proliferation • apoptotic process • prepulse inhibition • negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • regulation of myeloid cell apoptotic process • male mating behavior • regulation of protein stability • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • memory • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • learning or memory • social behavior • synapse assembly • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of focal adhesion assembly • negative regulation of dendritic spine morphogenesis • brain morphogenesis • negative regulation of protein phosphorylation • negative regulation of protein kinase B signaling • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of cell aging • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • protein dephosphorylation • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of apoptotic process • response to glucose • nervous system development • negative regulation of cell migration • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • phosphatidylinositol-mediated signaling • dephosphorylation • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • lipid metabolic process • aging • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • negative regulation of phosphatidylinositol 3-kinase signaling • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • T cell receptor signaling pathway • cell migration • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • response to drug • central nervous system neuron axonogenesis • long-term synaptic potentiation • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • positive regulation of ubiquitin protein ligase activity • protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5728


19211

Ensembl


n/a


ENSMUSG00000013663

UniProt


P60484


O08586

RefSeq (mRNA)


NM_000314 NM_001304717 NM_001304718


NM_008960 NM_177096

RefSeq (protein)


NP_000305 NP_001291646 NP_001291647 NP_000305.3


NP_032986.1 NP_032986

Location (UCSC)

Chr 10: 87.86 – 87.97 Mb

Chr 19: 32.76 – 32.83 Mb

PubMed search

4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ

n/a

NM_000314
NM_001304717
NM_001304718

NM_008960
NM_177096

NP_000305
NP_001291646
NP_001291647
NP_000305.3

NP_032986.1
NP_032986

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