PRMT5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4GQB, 4X60, 4X61, 4X63, 5EML, 5FA5, 5EMJ, 5EMK, 5EMM, 5C9Z

Identifiers

Aliases

PRMT5, HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs, Protein arginine methyltransferase 5

External IDs

MGI: 1351645 HomoloGene: 4454 GeneCards: PRMT5

EC number

2.1.1.125

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q11.2	Start	22,920,511 bp
Band	14q11.2	End	22,929,585 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 C2	Start	54,507,187 bp
Band	14\|14 C2	End	54,517,525 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• methyltransferase activity • transferase activity • histone methyltransferase activity (H4-R3 specific) • transcription corepressor activity • protein complex binding • methyl-CpG binding • core promoter sequence-specific DNA binding • protein binding • protein heterodimerization activity • ribonucleoprotein complex binding • histone-arginine N-methyltransferase activity • protein-arginine N-methyltransferase activity • protein-arginine omega-N symmetric methyltransferase activity
Cellular component	• cytoplasm • cytosol • Golgi apparatus • nucleoplasm • protein complex • methylosome • nucleus • histone methyltransferase complex
Biological process	• regulation of mitotic nuclear division • positive regulation of oligodendrocyte differentiation • regulation of transcription, DNA-templated • histone H4-R3 methylation • rhythmic process • DNA-templated transcription, termination • negative regulation of cell differentiation • peptidyl-arginine N-methylation • endothelial cell activation • circadian regulation of gene expression • transcription, DNA-templated • spliceosomal snRNP assembly • liver regeneration • methylation • peptidyl-arginine methylation • regulation of ERK1 and ERK2 cascade • regulation of DNA methylation • cell proliferation • Golgi ribbon formation • protein methylation • negative regulation of nucleic acid-templated transcription • positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway • covalent chromatin modification • regulation of signal transduction by p53 class mediator • peptidyl-arginine methylation, to symmetrical-dimethyl arginine
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10419


27374

Ensembl


ENSG00000100462


ENSMUSG00000023110

UniProt


O14744


Q8CIG8

RefSeq (mRNA)

NM_001039619 NM_001282953 NM_001282954 NM_001282955 NM_001282956
NM_006109


NM_013768 NM_001313906 NM_001313907

RefSeq (protein)

NP_001034708 NP_001269882 NP_001269883 NP_001269884 NP_001269885
NP_006100


NP_001300835 NP_001300836 NP_038796

Location (UCSC)

Chr 14: 22.92 – 22.93 Mb

Chr 14: 54.51 – 54.52 Mb

PubMed search

4GQB, 4X60, 4X61, 4X63, 5EML, 5FA5, 5EMJ, 5EMK, 5EMM, 5C9Z

NM_013768
NM_001313906
NM_001313907

NP_006100

NP_001300835
NP_001300836
NP_038796

...
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