PRKAR2B

PRKAR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TNP, 3TNQ, 4WBB, 4X6Q
Identifiers
Aliases	PRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta
External IDs	MGI: 97760 HomoloGene: 37666 GeneCards: PRKAR2B
Gene ontology Molecular function • nucleotide binding • protein domain specific binding • protein kinase A catalytic subunit binding • cAMP binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • protein kinase binding • ubiquitin protein ligase binding • protein binding • kinase activity Cellular component • cytoplasm • cytosol • centrosome • membrane • plasma membrane • dendritic spine • ciliary base • dendritic shaft • neuronal cell body • dendrite • perinuclear region of cytoplasm • mitochondrial inner membrane • membrane raft • cAMP-dependent protein kinase complex • extracellular exosome • postsynapse Biological process • regulation of protein phosphorylation • activation of protein kinase A activity • intracellular signal transduction • response to antipsychotic drug • cellular response to glucagon stimulus • blood coagulation • learning • negative regulation of cAMP-dependent protein kinase activity • fatty acid metabolic process • G2/M transition of mitotic cell cycle • response to clozapine • renal water homeostasis • regulation of protein kinase activity • ciliary basal body docking • phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5577	19088
Ensembl	ENSG00000005249	ENSMUSG00000002997
UniProt	P31323	P31324
RefSeq (mRNA)	NM_002736	NM_011158
RefSeq (protein)	NP_002727 NP_002727.2	NP_035288.2 NP_035288
Location (UCSC)	Chr 7: 107.04 – 107.16 Mb	Chr 12: 31.96 – 32.06 Mb
PubMed search

3TNP, 3TNQ, 4WBB, 4X6Q

5577

19088

ENSG00000005249

ENSMUSG00000002997

P31323

P31324

NM_002736

NM_011158

NP_002727
NP_002727.2

NP_035288.2
NP_035288

cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

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